Results 111 to 120 of about 189,838 (273)
, 2015 The Cutting Plane method is a simple and efficient method for optimizing convex functions in which subgradients are available. This paper proposes several methods for parallelizing it, in particular using a typically evolutionary method, and compares them experimentally in a well-conditioned and ill-conditioned settings.
Decock, Jérémie +2 more
openaire +1 more source
Cutting rectangles in the plane
Discrete Mathematics, 1982 AbstractLet F be a planar family of pairwise disjoint translates of a parallelogram. It is shown that if every four members of F are intersected by some straight line, then there is a straight line which intersects all but at most two members of F. If it is instead assumed that every two members of F are intersected by some line that is parallel to one
Katchalski, Meir, Lewis, Ted
openaire +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Results in EngineeringThis study proposes a unified two-dimensional (2D) polygon-based computer-aided manufacturing (CAM) framework that enables tool path generation, machinability evaluation, material removal simulation, and cutting-force prediction within a single ...
Kazuki Kaneko +3 more
doaj +1 more source
A Lagrangian relaxation approach to the edge-weighted clique problem [PDF]
, 1998 The $b$-clique polytope $CP^n_b$ is the convex hull of the node and edge incidence vectors of all subcliques of size at most $b$ of a complete graph on $n$ nodes.
Faigle, Ulrich +2 more
core +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Известия Иркутского государственного университета: Серия "Математика", 2015 In this paper it is considered the modified simplex imbeddings method, which is related to the class of cutting plane methods. The main feature of this method is the convergence estimation, which depends only on the quantity of simplex vertices, that are
A.V. Kolosnitcyn
doaj
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source