Results 71 to 80 of about 191,202 (337)
Revista Colombiana de Estadística, 2005 La regresión cuantílica es un problema de optimización convexa no diferenciable. Se examinan las ventajas y desventajas con relación a la necesidad de recursos de memoria y tiempo de cálculo de tres métodos clásicos de solución: dos de optimización ...
HÉCTOR MANUEL MORA ESCOBAR
doaj
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Analysis of the Technological Parameters of the Heat Exchanger in the Heating Pipe
MATEC Web of Conferences, 2017 The main purpose of this article is to analyze the selecting of technological parameters for the heat exchanger to improve the heat transfer and reduce the noise during operation in the heating pipe, which is used in the different systems of the planes ...
Knyazev Vladimir, Bubnov Gregory
doaj +1 more source
Computational medical imaging for total knee arthroplasty using visualitzation toolkit [PDF]
, 2015 This project is presented as a Master Thesis in the field of Civil Engineering, Biomedical specialization. As the project of an Erasmus exchange student, this thesis has been under supervision both the Universite Livre de Bruxelles and the Universitat ...
Romero Sánchez, José Javier
core +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Cutting Plane and Frege Proofs
Information and Computation, 1995 The cutting plane refutation system CP for classical propositional calculus [see \textit{W. Cook}, \textit{C. R. Coullard} and \textit{Gy. Turan}, Discrete Appl. Math. 18, 25-38 (1987; Zbl 0625.90056)], initially coming from works in operation research, can be considered as an extension of resolution based on showing the non-existence of solutions for ...
openaire +2 more sources
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Multiple Cuts in the Analytic Center Cutting Plane Method
SIAM Journal on Optimization, 2000 Summary: We analyze the multiple cut generation scheme in the analytic center cutting plane method. We propose an optimal primal and dual updating direction when the cuts are central. The direction is optimal in the sense that it maximizes the product of the new dual slacks and of the new primal variables within the trust regions defined by Dikin's ...
Goffin, Jean-Louis, Vial, Jean-Philippe
openaire +2 more sources
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source