Results 91 to 100 of about 7,476,610 (346)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Generation of cutting heat and simulation of core tube wall temperature during coring in primary structure coal seam

Heliyon
When the drilling core method is used to determine the coalbed gas content, the cutting heat generated by the core bit cutting coal will increase the core tube temperature, and the excessively high core tube temperature will have an heating effect on the
Shujun Ma, Zhaofeng Wang, Jiwei Yue, Fenghua An, Haidong Chen   +4 more
doaj   +1 more source

Suppression of tool wear by extremely short-duration cutting

Mechanical Engineering Journal, 2015
High-speed cutting has various advantages such as high material removal rates and reduction of machining time. However, the greatest problem of high-speed cutting is its excessive tool wear rate.
Yuki TERASAKA, Fumihiro ITOIGAWA, Satoru MAEGAWA, Takashi NAKAMURA   +3 more
doaj   +1 more source

Studies on cutting temperature by dimensional analysis (2nd report: Influence of thermal properties of workpiece and tool materials)

Nihon Kikai Gakkai ronbunshu, 2020
An evaluating equation to present the influence of thermal properties of workpiece and cutting tool on the cutting temperature is derived by the dimensional analysis.
Takashi UEDA, Seiichi UTO, Yuki HIRAI, Eiji SHAMOTO   +3 more
doaj   +1 more source

Workpiece surface temperature for in-process surface roughness prediction using response surface methodology [PDF]

, 2011
As manufacturing technology has been moving to the stage of full automation over the years, one of the fundamental requirements is the ability to accurately predict the output performance of machining processes.
Abdul Jalil, Nawal Aswan, Ismail, Napsiah, Suhail, Adeel H., Wong, Shaw Voon   +3 more
core   +1 more source

Application of an Adaptive “Neuro-Fuzzy” Inference System in Modeling Cutting Temperature during Hard Turning

Applied Sciences, 2019
The machining of hard materials with the most economical process is a challenge that is the aim of production systems. Increasing demands of the market require a hard processing hardened steel in order to avoid finishing grinding. This research considers
B. Savković, P. Kovac, B. Dudić, D. Rodić, Mirfad Taric, M. Greguš   +5 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The Loss of Some Strength Characteristics of Coated Magazine Paper as a Result of Exposure to Elevated Temperatures [PDF]

, 1954
Introduction The purpose of this work is to investigate the effect that varying degrees of temperature have on the strength properties of coated magazine stock.
Burnie, Hugh D.
core   +1 more source

Cutting rules in the real time formalisms at finite temperature [PDF]

, 1997
In this paper, we review the set of rules specific to the calculation of the imaginary part of a Green's function at finite temperature in the real-time formalisms.
Gelis, Francois
core   +2 more sources