Results 71 to 80 of about 718,654 (353)

Performance of laser assisted micro-milling (laμmill) of titanium alloy using micro ball end mill [PDF]

, 2018
Laser assisted milling technique turns to be complicated and unpredictable when the machining size is scaled to micro level. Furthermore, less has been reported on the application of ball end mill in laser assisted micro milling.
Mohid, Zazuli
core  

A response surface methodology and desirability approach for predictive modeling and optimization of cutting temperature in machining hardened steel [PDF]

, 2014
This paper presents an experimental investigation on cutting temperature during hard turning of EN 24 steel (50 HRC) using TiN coated carbide insert under dry environment.
Ashok Kumar Sahoo, Purna Chandra Mishra
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Experimental studies on cutting temperature and its effect in high speed turning of difficult-to-cut materials with ceramic tool

Nihon Kikai Gakkai ronbunshu, 2017
In high speed turning, six kinds of materials, namely, Ti-6Al-4V, Inconel718, SUS304, S50C, Copper and Aluminum are machined with a ceramic cutting tool in order to investigate the influence of the cutting speed on the temperature of the cutting tool ...
Takashi UEDA, Yuki HIRAI, Eiji SHAMOTO
doaj   +1 more source

Finite-temperature reaction-rate formula: Finite volume system, detailed balance, $T \to 0$ limit, and cutting rules [PDF]

, 1997
A complete derivation, from first principles, of the reaction-rate formula for a generic process taking place in a heat bath of finite volume is given. It is shown that the formula involves no finite-volume correction.
A. Das, A. H. Mueller, A. J. Niemi, A. J. Niemi, A. Niégawa, A. Niégawa, A. Niégawa, A. Niégawa, H. A. Weldon, H. Hata, M. Jacob, N. Ashida, N. Ashida, N. Ashida, N. Asida, N. Ohta, N. P. Landsman, P. F. Bedaque, P. V. Landshoff, R. E. Cutkosky, R. Kobes, R. L. Kobes, R. L. Kobes, S. Jeon, T. Kinoshita, T. S. Evans   +25 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

OPTIMIZATION OF THE CUTTING EDGE GEOMETRICAL PARAMETERS BASED ON FINITE ELEMENT SIMULATION OF TURNING INCONEL 718

Jixie qiangdu, 2015
A two-dimensional finite element model of orthogonal cutting Inconel 718 has been built by Third Wave Advant Edge to obtain the distribution of temperature and stress under different parameters of the cutting edge.
CHENG Xin, LIU QingFeng, WANG NingChang, JIANG Feng   +3 more
doaj  

Efficiency and Heat Production of Ultrasonic Osteotome Strategy in Robot-Assisted Laminectomy

Global Spine Journal
Study Design A biomechanical study. Objective We aimed to assess temperature fluctuations when applying the ultrasonic osteotome during laminectomy and identify the most appropriate cutting method for robot-assisted laminectomy to mitigate the risk of ...
Chengxia Wang MD, Zhuofu Li MD, Shuai Jiang MD, Woquan Zhong MD, Weishi Li MD   +4 more
doaj   +1 more source

Prediction of drilling temperature during low-frequency vibration drilling of titanium alloy

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2017
Low-frequency vibration drilling can suppress the drilling temperature and extend tool life. In low-frequency vibration drilling, there are drilling times and non-drilling times in each vibration cycle.
Kiyoshi OKAMURA, Hiroyuki SASAHARA
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source