Results 91 to 100 of about 718,654 (353)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Use of leaf thickness sensors in horticultural crops [PDF]

, 2017
Changes in leaf thickness can be a rapid indicator of the plant’s water status and can therefore serve as an alarm signal for potential water deficits. Combining the use of continuous leaf thickness measurements with a mechanistic plant model describing ...
De Pauw, Dirk, Lauriks, Fran, Steppe, Kathy, Van de Put, Hans   +3 more
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Generation of cutting heat and simulation of core tube wall temperature during coring in primary structure coal seam

Heliyon
When the drilling core method is used to determine the coalbed gas content, the cutting heat generated by the core bit cutting coal will increase the core tube temperature, and the excessively high core tube temperature will have an heating effect on the
Shujun Ma, Zhaofeng Wang, Jiwei Yue, Fenghua An, Haidong Chen   +4 more
doaj   +1 more source

Experimental Investigation and FE Simulation of the Effect of Variable Control on Temperature Distribution in Orthogonal Metal Cutting Process [PDF]

, 2016
The study aimed at building a 3-Dimensional finite element simulation to monitor orthogonal machining process under a dry machining environment. The study was conducted in two stages of experimentation and finite element modelling and simulation (FEMS ...
Agarana, M. C., Ajayi, O. O., Lawal, D.A, Ogbonnaya, Mercy   +3 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Suppression of tool wear by extremely short-duration cutting

Mechanical Engineering Journal, 2015
High-speed cutting has various advantages such as high material removal rates and reduction of machining time. However, the greatest problem of high-speed cutting is its excessive tool wear rate.
Yuki TERASAKA, Fumihiro ITOIGAWA, Satoru MAEGAWA, Takashi NAKAMURA   +3 more
doaj   +1 more source

The Loss of Some Strength Characteristics of Coated Magazine Paper as a Result of Exposure to Elevated Temperatures [PDF]

, 1954
Introduction The purpose of this work is to investigate the effect that varying degrees of temperature have on the strength properties of coated magazine stock.
Burnie, Hugh D.
core   +1 more source

Thermal transport in a spin-1/2 Heisenberg chain coupled to a (non) magnetic impurity

, 2010
We explore the effect of a (non) magnetic impurity on the thermal transport of the spin-1/2 Heisenberg chain model. This unique system allows to probe Kondo-type phenomena in a prototype strongly correlated system.
Barišić, O. S., Metavitsiadis, A., Prelovšek, P., Zotos, X.   +3 more
core   +1 more source

Causes of Quality Loss of Cut Flowers - A Critical Analysis of Post-Harvest Treatments [PDF]

, 2009
Temperature is one of the most important factors in the postharvest phase to control quality losses, yet temperature is still poorly managed, partly because its effects are not always understood well.
Meeteren, U., van
core   +2 more sources