Results 61 to 70 of about 718,654 (353)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Modeling and Measurement of Cutting Temperatures in Milling
Procedia CIRP, 2016 AbstractMilling is the one of most common cutting operations in industry. Interrupted nature of the milling process allows use of higher speeds which in turn improves productivity. Cutting temperature is one of the key factors to be investigated in process optimization.
Karagüzel, Umut +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Modelling and simulation on the tool wear in nanometric cutting [PDF]
, 2003 Tool wear is a significant factor affecting the machined surface quality. In this paper, a Molecular Dynamics (MD) simulation approach is proposed to model the wear of the diamond tool in nanometric cutting. It includes the effects of the cutting heat on
Cheng, K, Holt, R, Luo, X
core
Effect of boric acid mixture as solid lubricant towards machining processes [PDF]
, 2013 Milling is widely used metal removal process in manufacturing industry that involves generation of high cutting forces and temperature. Lubricants become important to reduce the cutting force and temperature for better machining processes and ...
Mohd Ariffin, Mohd Khairol Anuar +3 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Performance evaluation of biodegradable metalworking fluids for machining process [PDF]
, 2017 The widely use of metalworking fluids (MWFs) petroleum-based in the industry have a negative impact to the environment and human. Thus, various initiatives have been undertaken to develop bio-based MWFs especially from crude jatropha oil (CJO).
Talib, Norfazillah
core
Strong gate coupling of high-Q nanomechanical resonators
, 2010 The detection of mechanical vibrations near the quantum limit is a formidable challenge since the displacement becomes vanishingly small when the number of phonon quanta tends towards zero.
Fefferman, Andrew +7 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source