Results 51 to 60 of about 718,654 (353)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Simulation and Experimental Study on the Effect of Edge Radius on the Cutting Condition of Carbide Inserts

Machines
Carbide tools are extensively used in the automotive, aerospace, and marine industries. However, an unsuitable tool-edge treatment can affect the cutting performance of carbide tools.
Shitao Chen, Zhiyuan Bao, Yuhong Yan, Binghai Lyu, Hongyu Chen, Wei Hang, Jinhu Wang, Wenhong Zhao, Julong Yuan, Xu Wang   +9 more
doaj   +1 more source

DEM simulation of soil-tool interaction under extraterrestrial environmental effects [PDF]

, 2017
In contrast to terrestrial environment, the harsh lunar environment conditions include lower gravity acceleration, ultra-high vacuum and high (low) temperature in the daytime (night-time).
Arroyo Alvarez de Toledo, Marcos, Jiang, Mingjing, Rodríguez Dono, Alfonso, Xi, Banglu   +3 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Temperature simulation analysis and wear experimental of diamond abrasive grains cutting steel mixed materials

Jin'gangshi yu moliao moju gongcheng
ObjectivesDiamond wire saw cutting, being environmentally friendly and unaffected by water depth, structure material, shape, or size, has become the preferred method for dismantling large oceanic structures.
Min WEI, Yongjin SHI, Zihang GUO
doaj   +1 more source

FEA modeling of orthogonal cutting of steel: a review [PDF]

, 2012
Orthogonal cutting is probably the most studied machining operation for metals. Its simulation with the Finite Element Analysis (FEA) method is of paramount academic interest.
Borzan, Marian, De Waele, Wim, Galle, Timothy, Jula, Felicia Camelia   +3 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Digital image correlation as a usefful tool of analysis of hot cutting process [PDF]

, 2013
This study deals with the use of Digital Image Correlation (DIC) to investigate the physical phenomena taking place during the orthogonal cutting of a SG iron specimen at high temperature (around 1,000 °C).
EL MANSORI, Mohamed, FOUILLAND-PAILLE, Laurence, MOULART, Raphaël   +2 more
core   +3 more sources

Indirect monitoring method of tool wear using the analysis of cutting force during dry machining of Ti alloys [PDF]

, 2017
In recent decades, optimize tool life is in constant evolution so many researchers have focused to analysis the tool wear by indirect monitoring (e.g. acoustic emission, cutting forces, vibrations) that plays a significant role in control and improvement
Marcos, Mariano, Sanchez, Yezika, Sevilla-Hurtado, Lorenzo, Trujillo, Francisco Javier   +3 more
core   +2 more sources

A Review of the Effects of Temperature on the Cutting Edge of Cutting Tools

, 2023
Machining tools' longevity and optimal performance are prevalent problems in manufacturing. Instrument failure can result in significant financial losses, especially for small-scale manufacturers. Thus, this paper investigates the effects of temperature on the cutting edge to guide the design of effective cutting tools and processes.
Dr. Fahad Alhajri, Mohammed Hamad Alajmi
openaire   +1 more source