Results 101 to 110 of about 7,476,610 (346)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Thermocouple and Infrared Sensor-Based Measurement of Temperature Distribution in Metal Cutting

Sensors, 2015
In metal cutting, the magnitude of the temperature at the tool-chip interface is a function of the cutting parameters. This temperature directly affects production; therefore, increased research on the role of cutting temperatures can lead to improved ...
Abdil Kus, Yahya Isik, M. Cemal Cakir, Salih Coşkun, Kadir Özdemir   +4 more
doaj   +1 more source

Turning hardened steel using coated carbide at high cutting speeds [PDF]

, 2008
The present work studies some aspects of the turning process applied on hardened steel using multilayer coated carbide tools at high cutting speeds. The influence of cutting parameters (vc, f, and depth of cut - d.o.c.) on tool temperature, tool wear ...
ANEIRO, Federico M., BRANDÃO, Lincoln C., COELHO, Reginaldo T.   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Simulation and Experimental Research on the Longitudinal–Torsional Ultrasonic Cutting Process Characteristics of Aramid Honeycomb Materials

Applied Sciences
Aiming at the problems of large cutting force, easy honeycomb tearing, and deformation during the traditional cutting process of aramid honeycomb materials and an increase in cutting temperature during continuous processing, which may lead to vibration ...
Mingxing Zhang, Xinpeng Zhang, Linbin Li, Yuzhu Zhang, Liyuan Fang, Ting Meng, Xiaodong Wang   +6 more
doaj   +1 more source

Effect of sintering temperature on density, hardness and tool wear for alumina-zirconia cutting tool [PDF]

, 2019
Combination of alumina (Al2O3) and zirconia (ZrO2) as cutting tool have been established themselves as a dominant in ceramic category for dry machining. The mechanical properties of Al2O3-ZrO2 cutting tool were critically dependent on its density and
A. A., Afuza, A. B., Hadzley, M. F., Naim, M. M., Faiz, T., Norfauzi, U. A. A., Umar   +5 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Определение максимально возможной производительности лезвийной обработки с учетом ограничения по температуре резания [PDF]

, 2018
Аналитически определена температура резания при точении с учетом перемещения теплового источника вглубь поверхностного слоя обрабатываемой детали. Установлено, что увеличить производительность обработки можно уменьшением условного напряжения резания до ...
Полянский, Владимир Иванович
core  

Effect of Cutting Temperature on Bending Properties of Carbon Fibre Reinforced Plastics

Science and Engineering of Composite Materials, 2019
High cutting temperatures are easily generated during the machining of carbon fibre reinforced plastics (CFRP) and can induce serious damage during machining such as delamination. The purpose of this paper is to study the influence of cutting temperature
Ben Wang, Bowen Yang, Minghai Wang, Yaohui Zheng, Xianjun Hong, Fan-yun Zhang   +5 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source