Results 91 to 100 of about 867,518 (339)
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Modelling and simulation on the tool wear in nanometric cutting [PDF]
, 2003 Tool wear is a significant factor affecting the machined surface quality. In this paper, a Molecular Dynamics (MD) simulation approach is proposed to model the wear of the diamond tool in nanometric cutting. It includes the effects of the cutting heat on
Cheng, K, Holt, R, Luo, X
core
Simulation of the deflected cutting tool trajectory in complex surface milling [PDF]
, 2011 Since industry is rapidly developing, either locally or globally, manufacturers witness harder challenges due to the growing competitivity. This urges them to better consider the four factors linked to production and output: quality, quantity, cost and
Ali Zghal +18 more
core +3 more sources
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Investigation of tool geometry effect and penetration strategies on cutting forces during thread milling [PDF]
, 2014 The application of thread milling is increasing in industry because of its inherent advantages over other thread cutting techniques. The objective of this study is to investigate the effect of milling cutter tool geometry on cutting forces during thread ...
BRENDLEN, Romain +3 more
core +3 more sources
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Refrigerated cutting tools improve machining of superalloys [PDF]
, 1971 Freon-12 applied to tool cutting edge evaporates quickly, leaves no residue, and permits higher cutting rate than with conventional coolants.
Dudley, G. M.
core +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Effect of Shift in Speed Turning on Machined Surface Quality
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2017 This article describes the evaluation of machined material roughness in speed turning on a machining centre Doosan Puma 700 LY. The machined surface of semi-finished products from steel 14 260 was compared at selected cutting conditions.
Pavel Polák +2 more
doaj +1 more source
An Innovative Experimental Study of Corner Radius Effect on Cutting Forces [PDF]
, 2014 The cutting forces are often modelled using edge discretisation methodology. In finish turning, due to the smaller corner radii, the use of a local cutting force model identified from orthogonal cutting tests poses a significant challenge. In this paper,
BISSEY BRETON, Stéphanie +3 more
core +5 more sources