Results 91 to 100 of about 926,491 (359)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
LubricantsDuring machining, most of the mechanical energy is converted into heat. A substantial part of this heat is transferred to the cutting tool, causing a rapid rise in tool temperature. Excessive thermal loads accelerate tool wear and lead to displacement of
Hui Liu, Markus Meurer, Thomas Bergs
doaj +1 more source
Analysis of cutting parameters in point machining of parts with complex shape [PDF]
, 2018 This paper presents developed SW module in the postprocessor, which is designed to backward analysis of CAM milling toolpath. The module is designed to analyze multi-axis finishing machining of complex shape parts with milling cutters with a circular ...
Rybín J. +3 more
core
Displacements analysis of self-excited vibrations in turning
, 2009 The actual research deals with determining by a new protocol the necessary parameters considering a three-dimensional model to simulate in a realistic way the turning process on machine tool.
A Cowley +26 more
core +1 more source
Cutting-edge industrial technology of mining tool manufacturing [PDF]
, 2016 Purpose. To conduct a comparative economic analysis of cermet alloys regeneration technology, to identify the most “environmentally friendly” and cost-effective processing of solid alloys waste. Methods.
Gurenko, A, Naumenko, O, Savchenko, Iu
core +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Effect of Shift in Speed Turning on Machined Surface Quality
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2017 This article describes the evaluation of machined material roughness in speed turning on a machining centre Doosan Puma 700 LY. The machined surface of semi-finished products from steel 14 260 was compared at selected cutting conditions.
Pavel Polák +2 more
doaj +1 more source
Tool separates sleeve-type unions without heat [PDF]
, 1966 Tool that uses conventional milling and cutting techniques separates sleeve type tubing unions and tubes without using heat.
Millett, A. U.
core +1 more source
Atomistic aspects of ductile responses of cubic silicon carbide during nanometric cutting [PDF]
, 2011 Cubic silicon carbide (SiC) is an extremely hard and brittle material having unique blend of material properties which makes it suitable candidate for microelectromechanical systems and nanoelectromechanical systems applications.
Goel, Saurav +4 more
core +2 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source