Results 81 to 90 of about 3,910,373 (292)

Pre-evaluation on surface profile in turning process based on cutting parameters [PDF]

open access: yes, 2009
Traditional online or in-process surface profile (quality) evaluation (prediction) needs to integrate cutting parameters and several in-process factors (vibration, machine dynamics, tool wear, etc) for high accuracy.
MA, Ning   +3 more
core   +1 more source

Machinability improvement using high-pressure cooling in turning

open access: yesResearch in Agricultural Engineering, 2014
Process fluids are used primarily for their cooling and lubricating effect in machining. Many ways to improve their performance have been proposed; the analysis of some of them is provided in the paper.
R. Drlička, V. Kročko, M. Matúš
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Application of the Wigner distribution to monitoring cutting tool condition [PDF]

open access: yes
This thesis is about the application of the Wigner distribution to cutting tool monitoring and control. After reviewing traditional methods, a new method is proposed.
Zheng, Kougen
core  

Degradation modes and tool wear mechanisms in finish and rough machining of Ti17 Titanium alloy under high-pressure water jet assistance [PDF]

open access: yes, 2013
This article presents the results of an experimental study on the Ti17 titanium alloy, which was carried out to analyze tool wear and the degradation mechanisms of an uncoated tungsten carbide tool insert. Two machining conditions, roughing and finishing,
GERMAIN, Guénaël   +3 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Analysis of tribological parameters during machining [PDF]

open access: yes, 2009
In this paper, a hybrid analytical-numerical approach is performed for the orthogonal cutting process. The modelling of the thermomechanical material flow in the primary shear zone, the tool-chip contact length and the sliding-sticking zones are obtained
EL MANSORI, Mohamed   +8 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Tool wear monitoring and hole surface quality during CFRP drilling [PDF]

open access: yes, 2014
The present investigation focuses on the evaluation of tool wear and surface integrity in the context of CFRP cutting. Series of drilling experiments were performed on CFRP plates using cemented carbide solid drills with the aim to investigate ...
RAMIREZ, Christophe   +3 more
core   +1 more source

Identifying the cause of cutting tool failure by using simulation software

open access: yesMATEC Web of Conferences, 2018
The article is focused on the construction problems of cutting tools designed for manufacturing components in high numbers. Analysis of the tool with low lifetime is provided with the use of simulation software to detect the causes of the tool failure ...
Zrak Andrej, Koňár Radoslav
doaj   +1 more source

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