Results 91 to 100 of about 940,967 (310)
Automation of technological preparation of metal working on heavy machine tools [PDF]
, 2008 The programs for selection of the cutting tools construction and cutting regimes are working in unrestricted surroundings elaborate of addition SharpDevelop in language C#.
Leupers, Rainer +2 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
An experimental study of the effect of high-pressure water jet assisted turning (HPWJAT) on the surface integrity [PDF]
, 2011 This study deals with the effect of High-Pressure Water Jet Assisted Turning (HPWJAT) of austenitic stainless steels on chip shape and residual stresses. The machining of the austenitic stainless steels represents several difficulties. Recently, research
HABAK, Malek, LEBRUN, Jean-Lou
core +4 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
LubricantsDuring machining, most of the mechanical energy is converted into heat. A substantial part of this heat is transferred to the cutting tool, causing a rapid rise in tool temperature. Excessive thermal loads accelerate tool wear and lead to displacement of
Hui Liu, Markus Meurer, Thomas Bergs
doaj +1 more source
Design of a smart turning tool with application to in-process cutting force measurement in ultraprecision and micro cutting [PDF]
, 2014 In modern micromachining, there is a need to measure and monitor certain machining process parameters in process so as to detect tool wear in real time, to optimize the process parameters setup, and to render the machining process some level of smartness
Chen, X, Cheng, K, Wang, C
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Effect of Shift in Speed Turning on Machined Surface Quality
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2017 This article describes the evaluation of machined material roughness in speed turning on a machining centre Doosan Puma 700 LY. The machined surface of semi-finished products from steel 14 260 was compared at selected cutting conditions.
Pavel Polák +2 more
doaj +1 more source