Results 71 to 80 of about 176,368 (313)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Pre-evaluation on surface profile in turning process based on cutting parameters [PDF]
, 2009 Traditional online or in-process surface profile (quality) evaluation (prediction) needs to integrate cutting parameters and several in-process factors (vibration, machine dynamics, tool wear, etc) for high accuracy.
MA, Ning +3 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Experimental characterization of friction coefficients at the tool-chip-workpiece interface in cutting: Evaluation of lubrication efficiency of mineral oil [PDF]
, 2010 Collaboration avec le LTDS/ENISEThe characterization of friction coefficients at the tool-chip-workpiece interface remains an issue. This paper presents a new experimental set-up able to simulate similar tribological phenomena as the ones occurring at ...
RECH, Joël +4 more
core
Journal of Machine EngineeringUsing niobium carbide (NbC) for cutting materials is a promising alternative to tungsten carbide (WC) based cutting materials for metal machining due to the inherent material properties of NbC.
Eckart Uhlmann, Christoph Schneider
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Materials Research Express, 2020 Tool life of the traditional cutting tools is comparatively lesser on machining the martensitic stainless steel AISI 416 which is one of the hardest materials. In order to increase the tool life, wear-resistant nanocoatings on the cutting tools have been
Y Carlin Calaph +3 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Machinability improvement using high-pressure cooling in turning
Research in Agricultural Engineering, 2014 Process fluids are used primarily for their cooling and lubricating effect in machining. Many ways to improve their performance have been proposed; the analysis of some of them is provided in the paper.
R. Drlička, V. Kročko, M. Matúš
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source