Results 71 to 80 of about 3,910,373 (292)

Designing a special cutting tool for high performance machining of CuZn40Pb2 brass alloy

Journal of Advances in Manufacturing Engineering, 2021
In order to be competitive in manufacturing industries, it is essential to create high perfor-mance machining processes in manufacturing plant. One of the effective ways to improve the performance of machining processes is cutting tools.
Süleyman Çiçek, Adem Altun, Nima Zoghıpour1, Yusuf Kaynak   +3 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Numerical and analytical modeling of orthogonal cutting : The link between local variables and global contact characteristics [PDF]

, 2011
The response of the tool–chip interface is characterized in the orthogonal cutting process by numerical and analytical means and compared to experimental results. We study the link between local parameters (chip temperature, sliding friction coefficient,
Miguélez Garrido, María Henar, R. Cheriguene, MOLINARI, Alain, CHERIGUENE, Rachid, MIGUELEZ, Henar, A. Molinari, Molinari, A., H. Miguelez   +7 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Metal cutting modelling SPH approach [PDF]

, 2011
The purpose of this work is to evaluate the use of the smoothed particle hydrodynamics (SPH) method within the framework of high speed cutting modelling. First, a 2D SPH based model is carried out using the LS-DYNA® software.
J. Limido, Salaün, Michel, J.L. Lacome, R. Chieragatti, Lacome, Jean-Luc, M. Salaun, Chieragatti, Rémy, Mabru, Catherine, C. Espinosa, Espinosa, Christine, Limido, Jérôme, C. Mabru   +11 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Study on Machining Process of Multi-step Holes by Using The Standard Cutting Tool and Stepped Drill

Journal of Applied Engineering and Technological Science
Besides technological solutions, machining productivity is a factor that it is always considered by manufacturers. The cutting tool (CT) is one of the key points to boost the cutting efficiency and improve machining productivity of the machining process.
V. L. Trinh, T. S. Nguyen, K. T. Chu, V. H. Tran   +3 more
doaj   +1 more source

DESIGNING AND DEVELOPING A PROGRAM IN SINUMERIK vs. 1.3 FOR A SHAFT WITH SEALING GROOVES [PDF]

Fiabilitate şi Durabilitate, 2015
CNC is an abbreviation for „Computer Numerically Controlled". Numerically controlled tool machines are also called CNC machines.The numeric control results in a process of continuous „feeding” of an especially built programable controller, with a set ...
VALERIA VICTORIA IOVANOV
doaj  

Experimental and theoretical analysis of tool life between plasma enhanced CVD and PVD multilayer nanocoated cutting tools

Materials Research Express, 2020
Tool life of the traditional cutting tools is comparatively lesser on machining the martensitic stainless steel AISI 416 which is one of the hardest materials. In order to increase the tool life, wear-resistant nanocoatings on the cutting tools have been
Y Carlin Calaph, K Manikanda Subramanian, P Michael Joseph Stalin, N Sadanandam   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source