Results 61 to 70 of about 3,910,373 (292)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Experimental characterization of friction coefficients at the tool-chip-workpiece interface in cutting: Evaluation of lubrication efficiency of mineral oil [PDF]

, 2010
Collaboration avec le LTDS/ENISEThe characterization of friction coefficients at the tool-chip-workpiece interface remains an issue. This paper presents a new experimental set-up able to simulate similar tribological phenomena as the ones occurring at ...
RECH, Joël, FROMENTIN, Guillaume, DUMONT, Florian, MONDELIN, Alexandre, CLAUDIN, Christophe   +4 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A Comparative Study of Tool Wear for Niobium Carbide and Tungsten Carbide-Based Cutting Materials in Dry Cylindrical Turning

Journal of Machine Engineering
Using niobium carbide (NbC) for cutting materials is a promising alternative to tungsten carbide (WC) based cutting materials for metal machining due to the inherent material properties of NbC.
Eckart Uhlmann, Christoph Schneider
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Reliability assessment of cutting tools life based on advanced approximation methods [PDF]

, 2013
Cutting tools' reliability influences the whole manufacturing efficiency. However, in most cases the same cutting tool may be used for different operations with different processing parameters, making thus difficult to estimate the remaining life of the ...
Salonitis, Konstantinos, Kolios, Athanasios, Kolios, Athanasios J.   +2 more
core   +1 more source

Effect of MQL in high speed end-milling of Ti-6Al-4V with PVD coated tools

Nihon Kikai Gakkai ronbunshu, 2016
The high speed milling of Ti-6A-4V was investigated in order to clarify the efficiency of MQL and PVD coated tool. Cutting speed was very high 200m/min. TiAlN, TiCN, TiN, DLC and non-coated tools were used. Cooling methods were dry, wet and MQL (15mL/h).
Junsuke FUJIWARA, Takaaki ARIMOTO, Tetsuya TASHIRO   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

An investigation on the mechanics of nanometric cutting and the development of its test-bed [PDF]

, 2003
The mechanics of machining at a very small depth of cut (100 nm or less) is not well understood. The chip formation physics, cutting forces generation, resulting temperatures and the size effects significantly affect the efficiency of the process and ...
Cheng, K, Guo, XJ, Luo, X, Holt, R
core   +1 more source

Weight Reduction and Structural Optimization of a Face Milling Cutter Using DfAM

Applied Sciences
This study explores the application of design for additive manufacturing (DfAM) to modify the design of a face milling cutter, with the aim of reducing its weight. Conventional manufacturing methods often limit design flexibility, particularly for hollow
Jing-Hua Li, Hyun-Kyu Kweon, Goo-Sang Jung, Young-Hun Chae, Dong-Gyu Kim   +4 more
doaj   +1 more source