Results 61 to 70 of about 4,046,739 (289)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Journal of Machine EngineeringUsing niobium carbide (NbC) for cutting materials is a promising alternative to tungsten carbide (WC) based cutting materials for metal machining due to the inherent material properties of NbC.
Eckart Uhlmann, Christoph Schneider
doaj +1 more source
On Cutting Force Coefficient Model with Respect to Tool Geometry and Tool Wear [PDF]
, 2015 Cutting force models are important for machining processes simulations. This paper presents measurement of cutting forces during C45 (1.0503) carbon steel machining using a coated carbide tool.
Fojtů P., Kolář P., Schmitz T.
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Effect of MQL in high speed end-milling of Ti-6Al-4V with PVD coated tools
Nihon Kikai Gakkai ronbunshu, 2016 The high speed milling of Ti-6A-4V was investigated in order to clarify the efficiency of MQL and PVD coated tool. Cutting speed was very high 200m/min. TiAlN, TiCN, TiN, DLC and non-coated tools were used. Cooling methods were dry, wet and MQL (15mL/h).
Junsuke FUJIWARA +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Weight Reduction and Structural Optimization of a Face Milling Cutter Using DfAM
Applied SciencesThis study explores the application of design for additive manufacturing (DfAM) to modify the design of a face milling cutter, with the aim of reducing its weight. Conventional manufacturing methods often limit design flexibility, particularly for hollow
Jing-Hua Li +4 more
doaj +1 more source
Designing a special cutting tool for high performance machining of CuZn40Pb2 brass alloy
Journal of Advances in Manufacturing Engineering, 2021 In order to be competitive in manufacturing industries, it is essential to create high perfor-mance machining processes in manufacturing plant. One of the effective ways to improve the performance of machining processes is cutting tools.
Süleyman Çiçek +3 more
doaj
An investigation on the mechanics of nanometric cutting and the development of its test-bed [PDF]
, 2003 The mechanics of machining at a very small depth of cut (100 nm or less) is not well understood. The chip formation physics, cutting forces generation, resulting temperatures and the size effects significantly affect the efficiency of the process and ...
Cheng, K, Guo, XJ, Luo, X, Holt, R
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source