Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Tool separates sleeve-type unions without heat [PDF]
, 1966 Tool that uses conventional milling and cutting techniques separates sleeve type tubing unions and tubes without using heat.
Millett, A. U.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Cutting forces prediction: The experimental identification of orthogonal cutting coefficients [PDF]
FME Transactions, 2017 In this paper the cutting coefficients were identified applying the orthogonal cutting mechanics, which are used in the cutting forces and torque prediction. The experiments were performed for material combination of the workpiece (16MnCr5) and tool (HSS-
Popović Mihajlo +2 more
doaj
工程科学学报, 2017 Cutting energy can be transformed into cutting heat, which directly affects the cutting temperature. Therefore, it is important to understand the generation, transfer, and transformation of cutting energy to cutting temperature.
ZHAN Gang +3 more
doaj +1 more source
Cutting performance and wear characteristics of Si 3 N 4 –SiC w –HfB 2 ceramic cutting tools in turning of ductile cast iron [PDF]
, 2023 Qian‐Kun Gu +5 more
openalex +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
THERMAL PROCESSES RESEARCH DEVELOPMENT IN MACHINE-BUILDING TECHNOLOGY
Записки Горного института, 2018 The technique for determining the temperature in the surface layer of the workpiece with a blade tool is considered, taking into account the volume heat source in the cutting zone, on the basis of which it is proposed to calculate the processing errors ...
V. F. Bez"yazychnyi, M. Scherek
doaj +1 more source
Influence of CaF2@Al2O3 on Cutting Performance and Wear Mechanism of Al2O3/Ti(C,N)/CaF2@Al2O3 Self-Lubricating Ceramic Tools in Turning [PDF]
, 2020 Shuai Zhang +6 more
openalex +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source