Results 91 to 100 of about 838,874 (359)

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Optimization of broaching design [PDF]

, 2007
Broaching is one of the most recognized machining processes that can yield high productivity and high quality when applied properly. One big disadvantage of broaching is that all process parameters, except cutting speed, are built into the broaching ...
Budak, Erhan, Ozelkan, Ertunga, Ozturk, Ozkan, Özelkan, Ertunga, Öztürk, Özkan   +4 more
core  

Metal Laminated Tooling - A Quick and Flexible Tooling Concept [PDF]

, 2004
For the fast manufacturing of complex formed tools Fraunhofer IWS works together with partners from the industry on a constant automation solution for cutting, packaging and adding steel sheet cutouts.
Beyer, Eckhard, Himmer, Thomas, Nowotny, Steffen, Techel, Anja   +3 more
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Wear and corrosion properties of Cu–AlN composite coatings deposited by cold spray

Journal of Materials Research and Technology
Copper and copper alloy are commonly used to fabricate ship propellers and sealing valves that encounter harsh corrosion and wear. To improve their service life, Cu coating and Cu–AlN composite coatings with different volume content of AlN (10%, 20%, 30%)
Sheng Zhou, Jinfang Wang, Weili Wang, Ling Shao, Sheng Dai, Dongdong Zhu, Qingsong Lu, Meng Zhang, Yong Zhang, Liu Zhu   +9 more
doaj   +1 more source

Tool Life of PM-HSS Cutting Tools when Milling of Titanium Alloy [PDF]

, 2017
Machining of titanium alloys meets with poor life of a cutting tool. It is caused by a low thermal conductivity and by a high strength-to-weight ratio of the alloys. Various approaches for cost-effective and productive machining titanium alloys are still
Bach P., Trmal G., Zeman P.
core  

Communication research between working capacity of hardalloy cutting tools and fractal dimension of their wear [PDF]

, 2016
The results of communication research between the wear resistance of the Kapplicability hard-alloy cutting tools and the fractal dimension of the wear surface,which is formed on a back side of the cutting edge when processing the materialsshowing high ...
Arefyev (Afef'ev, Arefiev), Konstantin Petrovich, Daneykina (Daneikina), Natalia Viktorovna, Nesterenko, Vladimir Petrovich   +2 more
core   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Evaluation of tribo-vibration characteristics of the finishing turning process of heat-resistant structural steel 20MnMoNi5-5 [PDF]

E3S Web of Conferences
This article is devoted to determining the rational range of cutting speeds during longitudinal finish turning of heat-resistant steel 20MnMoNi5-5 based on a set of tribological and vibration parameters of the cutting process.
Gvindjiliya Valery, Fominov Evgeny, Moiseev Denis, Lavrenova Tatyana   +3 more
doaj   +1 more source