Results 91 to 100 of about 6,421,048 (404)
A comparative study of using spindle motor power and eddy current for the detection of tool conditions in milling processes [PDF]
, 2015 This paper investigates the use of the power of the driving motor of a CNC spindle in comparison to two perpendicular eddy current sensors for the detection of tool wear in milling processes. Monitoring the power through the current profile is a low cost
Abbass, JK, Al-Habaibeh, A
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Investigating the performance of TiN and TiAIN coatings on milling cutter used for machining bimetal steel strip [PDF]
, 2009 Surface engineering of cutting tools (single point or multipoint) through advanced coatings (e.g., TiN) has contributed towards considerable improvement of tool life, productivity and machining quality [1] by modifying the tool substrate.
Haider, Julfikar, Sarwar, Mohammed
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Materials & DesignThis study investigates the effect of Te addition combined with post-drawing heat treatment on the phase constitution, microstructure, microhardness, and corrosion behavior of Ag-based alloy wires.
Yizhe Liu +13 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Coating performance in high speed micro machining of H13 tool steel [PDF]
, 2010 The development and application of Titanium Aluminium Nitrate (TiAlN) coatings for cutting tools has led to dramatic tool life extension and the realisation of high speed machining for hardened materials.
Abdul Aziz, Faieza +4 more
core +1 more source
Effect of laser texturing on the performance of ultra-hard single-point cutting tools
The International Journal of Advanced Manufacturing Technology, 2019 This paper investigates the cutting performance and anti-adhesive properties of textured single-point polycrystalline diamond (PCD) cutting tools in machining Aluminium 6082 alloys.
P. Ghosh, M. Pacella
semanticscholar +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source