Results 61 to 70 of about 10,078 (243)

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, EarlyView.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source

Estimating relative CWD susceptibility and disease progression in farmed white-tailed deer with rare PRNP alleles

bioRxiv, 2019
Chronic wasting disease is a prion disease affecting both free-ranging and farmed cervids in North America and Scandinavia. A range of cervid species have been found to be susceptible, each with variations in the gene for the normal prion protein, PRNP ...
N. Haley, K. Merrett, A. Buros Stein, Dennis A. Simpson, Andrew Carlson, Gordon Mitchell, A. Staškevičius, T. Nichols, A. Lehmkuhl, B. Thomsen   +9 more
semanticscholar   +1 more source

Enhanced Sensitivity of a Modified Quaking‐Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study

Annals of Neurology, EarlyView.
Objective Quaking‐induced conversion (QuIC) tests, which detect prion‐seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt‐Jakob disease (CJD). These tests provide high diagnostic accuracy and enable timely differentiation from other rapidly progressive neurodegenerative ...
Jennifer Myskiw, Rebecca Fox, Dominic M.S. Kielich, Lise Lamoureux, Melanie Leonhardt, Olivia Nykvist, Jessy A. Slota, Kristen Avery, Clark Phillipson, Kathy Frost, Sharon Simon, Brian S. Appleby, Ben A. Bailey‐Elkin, Stephanie A. Booth   +13 more
wiley   +1 more source

Decay and nutrient dynamics of coarse woody debris in the Qinling Mountains, China.

PLoS ONE, 2017
As an ecological unit, coarse woody debris (CWD) plays an essential role in productivity, nutrient cycling, carbon sequestration, community regeneration and biodiversity. However, thus far, the information on quantification the decomposition and nutrient
Jie Yuan, Lin Hou, Xin Wei, Zhengchun Shang, Fei Cheng, Shuoxin Zhang   +5 more
doaj   +1 more source

Alterations in gut microbiota linked to provenance, sex, and chronic wasting disease in white-tailed deer (Odocoileus virginianus)

Scientific Reports, 2021
Chronic wasting disease (CWD) is a fatal, contagious, neurodegenerative prion disease affecting both free-ranging and captive cervid species. CWD is spread via direct or indirect contact or oral ingestion of prions.
David Minich, Christopher Madden, Morgan V. Evans, Gregory A. Ballash, Daniel J. Barr, Keith P. Poulsen, Patricia M. Dennis, Vanessa L. Hale   +7 more
doaj   +1 more source

Assessing Past and Future Temperature‐ and Precipitation‐Based Indicators in the Republic of Yemen

International Journal of Climatology, EarlyView.
For the first time in the literature, this work assesses the past and future climatic trends over Yemen, a highly vulnerable country for which science‐based, high‐quality information for the development of climate change adaptation plans was not available until now.
Jorge Alvar‐Beltrán, Rodrigo Manzanas, Anika Seggel, Abdulwahid Arman, Ana Casanueva, Riccardo Soldan   +5 more
wiley   +1 more source

Occurrence, Transmission, and Zoonotic Potential of Chronic Wasting Disease

Emerging Infectious Diseases, 2012
Chronic wasting disease (CWD) is a fatal, transmissible prion disease that affects captive and free-ranging deer, elk, and moose. Although the zoonotic potential of CWD is considered low, identification of multiple CWD strains and the potential for agent
Samuel E. Saunders, Shannon L. Bartelt-Hunt, Jason C. Bartz   +2 more
doaj   +1 more source

Projected Intensification of Hydroclimatic Extremes in Rio Grande do Norte, Brazil, Under CMIP6 Scenarios

International Journal of Climatology, EarlyView.
The graphical abstract presents observed (1963–2023) and projected changes in hydroclimatic extremes in Rio Grande do Norte, Brazil. It integrates dry‐spell duration (CDD) and extreme precipitation (R95pTOT) using CMIP6 multimodel ensembles under SSP1‐2.6, SSP2‐4.5, and SSP5‐8.5.
Daris Correia dos Santos
wiley   +1 more source

Mastoid Surgery Does Not Normalize Tympanometric Middle Ear Pressure in Children With Cholesteatoma

The Laryngoscope, EarlyView.
Conflicting mechanism‐based hypotheses have been used to promote selection of different approaches to management of the mastoid in order to optimize middle ear pressure homeostasis after removal of cholesteatoma. For example: (a) conservation of mastoid mucosa and opening of ventilation pathways endoscopically to normalize function, (b) removal of ...
Adrian L. James
wiley   +1 more source

Mesna in Otologic Surgery: Efficacy and Safety—A Scoping Review

The Laryngoscope, EarlyView.
PRISMA flow diagram indicating the process of systematic inclusion and exclusion of articles. ABSTRACT Objective Mesna (Sodium 2‐mercaptoethanesulfonate) is widely used as a mucolytic agent and uroprotective agent. Recently, its disulfide bond‐breaking property has been applied in otologic surgery to facilitate safer dissection of cholesteatoma and ...
Kevork H. Atamian, Inabat Yermesheva, Ostap Orishchak, Hady Tall, Sam J. Daniel   +4 more
wiley   +1 more source