Results 1 to 10 of about 17,635 (197)

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis [PDF]

Advanced Science
The skin's unique thermosensitivity renders it exceptionally responsive to thermal perturbations, wherein heat stress exposure disrupts cutaneous homeostasis and activates pigmentary pathways.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
doaj   +3 more sources

CX3CL1 release during immunogenic apoptosis is associated with enhanced anti-tumour immunity [PDF]

Frontiers in Immunology
IntroductionImmunogenic cell death (ICD) has emerged as a novel option for cancer immunotherapy. The key determinants of ICD encompass antigenicity (the presence of antigens) and adjuvanticity, which involves the release of damage-associated molecular ...
Faye Naessens, Faye Naessens, Robin Demuynck, Robin Demuynck, Olga Vershinina, Iuliia Efimova, Iuliia Efimova, Mariia Saviuk, Mariia Saviuk, Greet De Smet, Tatiana A. Mishchenko, Maria V. Vedunova, Olga Krysko, Elena Catanzaro, Elena Catanzaro, Dmitri V. Krysko, Dmitri V. Krysko   +16 more
doaj   +3 more sources

CX3CL1 and its receptor CX3CR1 interact with RhoA signaling to induce paclitaxel resistance in gastric cancer

Heliyon
C-X3-C motif chemokine ligand 1 (CX3CL1) is a transmembrane protein, and the membranal and soluble forms of CX3CL1 exhibit different functions, although both bind to the CX3CR1 chemokine receptor.
Xiangyang Liu, Zhonghui Yu, Yun Li, Junzi Huang   +3 more
doaj   +3 more sources

Double-faced CX3CL1 enhances lymphangiogenesis-dependent metastasis in an aggressive subclone of oral squamous cell carcinoma

JCI Insight
Because cancer cells have a genetically unstable nature, they give rise to genetically different variant subclones inside a single tumor. Understanding cancer heterogeneity and subclone characteristics is crucial for developing more efficacious therapies.
Htoo Shwe Eain, Hotaka Kawai, Masaaki Nakayama, May Wathone Oo, Toshiaki Ohara, Yoko Fukuhara, Kiyofumi Takabatake, Quisheng Shan, Yamin Soe, Kisho Ono, Keisuke Nakano, Nobuyoshi Mizukawa, Seiji Iida, Hitoshi Nagatsuka   +13 more
doaj   +3 more sources

A systematic pan-cancer analysis reveals the clinical prognosis and immunotherapy value of C-X3-C motif ligand 1 (CX3CL1) [PDF]

Frontiers in Genetics, 2023
It is now widely known that C-X3-C motif ligand 1 (CX3CL1) plays an essential part in the process of regulating pro-inflammatory cells migration across a wide range of inflammatory disorders, including a number of malignancies. However, there has been no
Yidi Sun
doaj   +2 more sources

Alpha-toxin-elicited CX3CL1 release in Staphylococcus aureus pneumonia impairs bactericidal function of human monocytes [PDF]

mBio
Staphylococcus aureus is an important human pathogen causing severe invasive infections. Pathogenesis is attributed to a wide array of virulence factors, including several potent exotoxins such as the pore-forming α-toxin.
Srikanth Mairpady Shambat, Puran Chen, Rocky M. Barilla, Markus Huemer, Johanna Snäll, Amanda Welin, Taylor S. Cohen, Virginia Takahashi, Samuel B. Berry, Alejandro Gómez-Mejia, Tiziano A. Schweizer, Danen M. Cunoosamy, Sara Cajander, Magda Lourda, Volkan Özenci, Ewerton Marques Maggio, Reto A. Schüpbach, Kristoffer Strålin, Annelies S. Zinkernagel, Anna Norrby-Teglund, Mattias Svensson   +20 more
doaj   +2 more sources

The Role of the CX3CR1-CX3CL1 Axis in Respiratory Syncytial Virus Infection and the Triggered Immune Response [PDF]

International Journal of Molecular Sciences
Respiratory syncytial virus (RSV) is a common respiratory pathogen that causes respiratory illnesses, ranging from mild symptoms to severe lower respiratory tract infections in infants and older adults.
Selma Rivas-Fuentes, Alfonso Salgado-Aguayo, Teresa Santos-Mendoza, Edgar Sevilla-­Reyes   +3 more
openalex   +2 more sources

Evaluation of the levels of Fractalkine (CX3CL1), TNF-α, and TGF-β in the gingival crevicular fluid/tissue of patients with gingival overgrowth: a cross-sectional observational study [PDF]

Journal of Applied Oral Science
Fractalkine (CX3CL1) is expressed by various cells, contributing to the pathogenesis of diseases such as diabetes mellitus, vascular pathologies, and rheumatoid arthritis via immunological mechanisms.
Nazife HAMURCU, Ahu Uraz ÇÖREKCI, Rahşan Ilikçi SAĞKAN, Serpil CULA, Deniz Özbay ÇETINER   +4 more
doaj   +2 more sources

Diagnostic potential of urinary CX3CL1 for amnestic mild cognitive impairment and Alzheimer’s disease [PDF]

Frontiers in Aging Neuroscience
IntroductionThe role of the chemokine CX3CL1 in the processes of aging and Alzheimer’s disease (AD) pathogenesis is well-established. This study aims to evaluate the diagnostic potential of urinary CX3CL1 levels in distinguishing between AD patients ...
Yali Xu, Yali Xu, Jie Zhang, Jie Zhang, Ying-Ying Shen, Wei-Wei Li, Bin Li, Hai-Ping Cheng, Gui-Hua Zeng   +8 more
doaj   +2 more sources

Induction of CX3CL1 expression by LPS and its impact on invasion and migration in oral squamous cell carcinoma

Frontiers in Cell and Developmental Biology
Purpose: This study aimed to explore the expression of CX3CL1 induced by lipopolysaccharide (LPS) in oral squamous cell carcinoma (OSCC) and its impact on biological characteristics such as invasion and migration, taking the foundation for new targets ...
Chanjuan He, Chanjuan He, Yuehan Wu, Yuehan Wu, Xiaoxu Nan, Xiaoxu Nan, Weifang Zhang, Yu Luo, Yu Luo, Honglan Wang, Honglan Wang, Mengqi Li, Mengqi Li, Changyue Liu, Changyue Liu, Jiaming Liu, Jiaming Liu, Xuelin Mou, Xuelin Mou, Ying Liu, Ying Liu   +20 more
doaj   +2 more sources