Results 11 to 20 of about 17,635 (197)

CX3CL1 promotes M1 macrophage polarization and osteoclast differentiation through NF-κB signaling pathway in ankylosing spondylitis in vitro

Journal of Translational Medicine, 2023
Background Ankylosing spondylitis (AS) is an autoimmune disease with a genetic correlation and is characterized by inflammation in the axial skeleton and sacroiliac joints.
Xinzhe Feng, Shanbang Zhu, Junjie Qiao, Zhou Ji, Bole Zhou, Weidong Xu   +5 more
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CX3CL1 deficiency ameliorates acute kidney injury by inhibiting macrophage mitochondrial dysfunction and mtDNA-cGAS-STING signaling [PDF]

Cell Death Discovery
Dysregulated mitochondrial dynamics and macrophage-driven inflammation are essential contributors to the pathogenesis of acute kidney injury (AKI).
Qiming Gong, Fahui Liu, Yuqing Huang, Dehui Li, Tingting Zhou, Chen Zeng, Yan Jiang, Huang Wei, Yong Xu   +8 more
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CX3CL1-CX3CR1 axis protects retinal ganglion cells by inhibiting microglia activation in a distal optic nerve trauma model

Inflammation and Regeneration
Background The chemokine CX3CL1 has been reported to play an important role in optic nerve protection, but the underlying mechanism is still unclear. CX3CR1, the only receptor of CX3CL1, is specifically expressed on retinal microglia, whose activation ...
Huan Yu, Bingqiao Shen, Ruiqi Han, Yang Zhang, Shushu Xu, Yumeng Zhang, Yanzhi Guo, Ping Huang, Shouyue Huang, Yisheng Zhong   +9 more
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The chemokine CX3CL1 promotes intraperitoneal tumour growth despite enhanced T-cell recruitment in ovarian cancer

Neoplasia: An International Journal for Oncology Research
T-cell recruiting chemokines are required for a successful immune intervention in ovarian cancer, and also for the efficacy of modern anticancer agents such as PARP inhibitors.
Stefanie Seitz, Tobias F. Dreyer, Christoph Stange, Katja Steiger, Dirk Wohlleber, Martina Anton, Thuý An Pham, Dominique Sauter-Peschke, Ute Reuning, Gabriele Multhoff, Wilko Weichert, Marion Kiechle, Viktor Magdolen, Holger Bronger   +13 more
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CX3CL1 promotes M1 macrophage polarization and osteoclast differentiation via NSUN5-mediated m5C modification [PDF]

Scientific Reports
Bone homeostasis refers to a dynamic equilibrium maintained between osteogenesis and osteoclastic bone resorption within the skeletal system. CX3CL1 (Fractalkine) is a chemokine that plays a significant regulatory role in bone homeostasis.
Zhibin Deng, Wei Zhong
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An overview of the role of chemokine CX3CL1 (Fractalkine) and CX3C chemokine receptor 1 in systemic sclerosis

Immunity, Inflammation and Disease
Introduction Systemic sclerosis (SSc) is a complex autoimmune disease characterized by fibrosis, vascular damage, and immune dysregulation. Fractalkine or chemokine (C‐X3‐C motif) ligand 1 (CX3CL1), a chemokine and adhesion molecule, along with its ...
Fatemehsadat Pezeshkian, Reza Shahriarirad, Hadiseh Mahram   +2 more
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CX3CL1/Fractalkine: A Potential Biomarker for Liver Fibrosis in Chronic HBV Infection

Current Issues in Molecular Biology
A hepatitis B virus (HBV) infection can progress to chronic hepatitis, leading to liver fibrosis, cirrhosis, and hepatocellular carcinoma. CX3CL1/Fractalkine plays a crucial role in recruiting immune cells that are responsible for protecting against HBV ...
Natalia A. Arsentieva, Zoia R. Korobova, Oleg K. Batsunov, Natalia E. Lyubimova, Valentina V. Basina, Elena V. Esaulenko, Areg A. Totolian   +6 more
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The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders

Cells, 2020
Fractalkine (FKN, CX3CL1) is a transmembrane chemokine expressed by neurons in the central nervous system (CNS). CX3CL1 signals through its unique receptor, CX3CR1, that is expressed in microglia.
Paulina Pawelec, Malgorzata Ziemka-Nalecz, Joanna Sypecka, Teresa Zalewska   +3 more
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Exploring the causal relationship between CX3CL1 and prostate cancer prognosis using Mendelian randomization [PDF]

Discover Oncology
Background Prostate cancer (PCa) is a common cancer in men, making up about 21% of male cancer cases worldwide. Although prostate cancer is common, little is known about its causes, which makes treatment more difficult.
Weisheng Li, Baoguo Xia, Weixin Chu, Likui Lu, Xuedong Liu   +4 more
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Chemokine expression in patients with ovarian cancer or benign ovarian tumors

Archives of Medical Science, 2021
Introduction Chemokines play a crucial role in tumor growth and progression according to proangiogenic and immunosuppressive action. The aim of this study was to investigate the serum levels of selected chemokines in patients with ovarian cancer or ...
Marek Nowak, Łukasz Janas, Malwina Soja, Ewa Głowacka, Krzysztof Szyłło, Marcin Misiek, Magdalena Klink   +6 more
doaj   +1 more source