Results 191 to 197 of about 17,635 (197)

Pathophysiological Roles of the CX3CL1-CX3CR1 Axis in Renal Disease, Cardiovascular Disease, and Cancer

International Journal of Molecular Sciences
CX3CL1 and its unique receptor, CX3CR1, are leukocyte migration factors and are involved in the pathogenesis and progression of many inflammatory diseases and malignancies.
Y. Iwahashi, Y. Ishida, N. Mukaida, T. Kondo   +3 more
semanticscholar   +1 more source

Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3cl1 axis.

Cancer Letters
Metastasis is the main culprit of cancer-related death and account for the poor prognosis of hepatocellular carcinoma. Although platelets have been shown to accelerate tumor cell metastasis, the exact mechanism remained to be fully understood.
Jia-Hui Gao, Ao-di He, Lu-Man Liu, Ya-jun Zhou, Ya-wei Guo, Meng Lu, Xiang-Bin Zeng, X. Gong, Yong-Jie Lu, Hui-fang Liang, Bi-xiang Zhang, Rong Ma, Ru-Yi Zhang, Zhang-Yin Ming   +13 more
semanticscholar   +1 more source

CX3CL1 represses autophagy via CX3CR1/ CaMKIIδ/HDAC4/Rubicon axis and exacerbates chronic intermittent hypoxia induced Kupffer cell apoptosis.

Cellular Signalling, 2023
BACKGROUND Nocturnal hypoxemia is an established factor in the pathogenesis and exacerbation of term metabolic (dysfunction) associated fatty liver disease (MAFLD).
Yayong Li, Yuanguo Chen, X. Xiao, Silei Deng, J. Kuang, Yi-na Wang   +5 more
semanticscholar   +1 more source

CX3CL1 inhibits NLRP3 inflammasome-induced microglial pyroptosis and improves neuronal function in mice with experimentally-induced ischemic stroke.

Life Science, 2022
AIMS Stroke represents the second cause of mortality across the globe and develops following the interruption of cerebral blood circulation. The chemokine CX3CL1 and its receptor CX3CR1 play a fundamental role in the pathophysiology of ischemic stroke ...
Yang-yang Ge, Li Wang, Chenchen Wang, Jiayi Chen, Maosha Dai, S. Yao, Yun Lin   +6 more
semanticscholar   +1 more source

Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling

Arteriosclerosis, Thrombosis and Vascular Biology
BACKGROUND: Heterogeneity in the severity of cerebral cavernous malformations (CCMs) disease, including brain bleedings and thrombosis that cause neurological disabilities in patients, suggests that environmental, genetic, or biological factors act as ...
Eduardo Frias-Anaya, Helios Gallego-Gutiérrez, Brendan Gongol, S. Weinsheimer, Catherine C. Lai, Marco Orecchioni, Aditya Sriram, Cassandra Bui, Bliss Nelsen, Preston Hale, Angela Pham, R. Shenkar, Dorothy DeBiasse, R. Lightle, R. Girard, Ying Li, Abhinav Srinath, R. Daneman, E. Nudleman, Hao Sun, M. Guma, Alexandre Dubrac, O. Mesarwi, Klaus Ley, Helen Kim, I. Awad, Mark H. Ginsberg, M. A. Lopez-Ramirez   +27 more
semanticscholar   +1 more source

Neutralization of CX3CL1 Attenuates TGF-β-Induced Fibroblast Differentiation Through NF-κB Activation and Mitochondrial Dysfunction in Airway Fibrosis

Lung
Wun-Hao Cheng, Pao-Lung Chang, Yu-Chih Wu, Shao-an Wang, Chia-Ling Chen, Feng-Lin Hsu, Mei-May Neoh, Lee-Yuan Lin, Fara S Yuliani, Chien-Huang Lin, Bing-Chang Chen   +10 more
semanticscholar   +1 more source

Treadmill Exercise Enhances Post-Stroke Functional Recovery in Mice via the CX3CL1/CX3CR1 Signaling Pathway

Molecular Neurobiology
Yang-yang Ge, Xiaoke Dou, Pu Chen, Jiayi Chen, Maosha Dai, Shanglong Yao, Yun Lin   +6 more
semanticscholar   +1 more source