Results 21 to 30 of about 17,635 (197)

Implications of fractalkine on glial function, ablation and glial proteins/receptors/markers—understanding its therapeutic usefulness in neurological settings: a narrative review

Future Journal of Pharmaceutical Sciences, 2022
Background Fractalkine (CX3CL1) is a chemokine predominantly released by neurons. As a signaling molecule, CX3CL1 facilitates talk between neurons and glia. CX3CL1 is considered as a potential target which could alleviate neuroinflammation.
Deepraj Paul, Duraiswamy Basavan
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CX3CL1 Worsens Cardiorenal Dysfunction and Serves as a Therapeutic Target of Canagliflozin for Cardiorenal Syndrome

Frontiers in Pharmacology, 2022
The prognosis of cardiorenal dysfunction induced by diabetes mellitus (DM), which belongs to cardiorenal syndrome type 5, is poor and its pathogenesis remains elusive. We have reported that CX3CL1 exacerbated heart failure and direct inhibition of CX3CL1
Cankun Zheng, Wanling Xuan, Zhenhuan Chen, Zhenhuan Chen, Rui Zhang, Xiaoxia Huang, Yingqi Zhu, Siyuan Ma, Kaitong Chen, Lu Chen, Mingyuan He, Hairuo Lin, Wangjun Liao, Jianping Bin, Jianping Bin, Yulin Liao, Yulin Liao   +16 more
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CX3CL1 promotes cell sensitivity to ferroptosis and is associated with the tumor microenvironment in clear cell renal cell carcinoma

BMC Cancer, 2022
Background An increasing number of studies have demonstrated that CX3CL1 is involved in the development of tumors and may thus be considered a new potential therapeutic target for them.
Qiming Gong, Zhiting Guo, Wenjuan Sun, Xiuri Du, Yan Jiang, Fahui Liu   +5 more
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RELATIONSHIP BETWEEN THE BLOOD LEVELS OF INFLAMMATORY CYTOKINES AND THE NUMBER OF CIRCULATING TUMOR CELLS WITH RESPONSE TO STANDARD CHEMOTHERAPY IN PATIENTS WITH OVARIAN CANCER

Сибирский онкологический журнал, 2021
Introduction. Serum chemokines are inflammatory mediators, which role is shown in the occurrence and progression of a number of malignant tumors. Produced by white blood cells, stem cells, tumor and endothelial cells, chemokines control their movement ...
S. O. Gening, A. A. Rizvanov, T. V. Abakumova, D. R. Dolgova, D. U. Gafurbaeva, A. R. Rakhmatullina, I. I. Antoneeva, T. P. Gening   +7 more
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Blocking postsynaptic density-93 binding to C-X3-C motif chemokine ligand 1 promotes microglial phenotypic transformation during acute ischemic stroke

Neural Regeneration Research, 2023
We previously reported that postsynaptic density-93 mediates neuron-microglia crosstalk by interacting with amino acids 357–395 of C X3 C motif chemokine ligand 1 (CX3CL1) to induce microglia polarization.
Xiao-Wei Cao, Hui Yang, Xiao-Mei Liu, Shi-Ying Lou, Li-Ping Kong, Liang-Qun Rong, Jun-Jun Shan, Yun Xu, Qing-Xiu Zhang   +8 more
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The Role of CX3CL1 and ADAM17 in Pathogenesis of Diffuse Parenchymal Lung Diseases

Diagnostics, 2021
Fractalkine (CX3CL1) is a unique chemokine that functions as a chemoattractant for effector cytotoxic lymphocytes and macrophages expressing fractalkine receptor CX3CR1. CX3CL1 exists in two forms—a soluble and a membrane-bound form.
Jan Urban, Magda Suchankova, Martina Ganovska, Vladimir Leksa, Frantisek Sandor, Eva Tedlova, Brian Konig, Maria Bucova   +7 more
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Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1

Disease Models & Mechanisms, 2019
Tendon disorders frequently occur and recent evidence has clearly implicated the presence of immune cells and inflammatory events during early tendinopathy. However, the origin and properties of these cells remain poorly defined.
Christine Lehner, Gabriel Spitzer, Renate Gehwolf, Andrea Wagner, Nadja Weissenbacher, Christian Deininger, Katja Emmanuel, Florian Wichlas, Herbert Tempfer, Andreas Traweger   +9 more
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Augmented concentrations of CX3CL1 are associated with interstitial lung disease in systemic sclerosis. [PDF]

PLoS ONE, 2018
BACKGROUND:Dysregulation of Fractalkine (CX3CL1) and its receptor CX3CR1 has been linked to the pathobiology of chronic inflammatory conditions. We explored CX3CL1 in systemic sclerosis (SSc) related progressive interstitial lung disease (ILD) and ...
Anna-Maria Hoffmann-Vold, Stephen Samuel Weigt, Vyacheslav Palchevskiy, Elizabeth Volkmann, Rajan Saggar, Ning Li, Øyvind Midtvedt, May Brit Lund, Torhild Garen, Michael C Fishbein, Abbas Ardehali, David J Ross, Thor Ueland, Pål Aukrust, Joseph P Lynch, Robert M Elashoff, Øyvind Molberg, John A Belperio   +17 more
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CX3CL1 as potential immunotherapeutic tool for bone metastases in lung cancer: A preclinical study

Advances in Cancer Biology - Metastasis, 2022
The chemokine CX3CL1 emerges as a double-edged sword in the pathophysiology of cancer. We investigated whether CX3CL1 would act as an impediment or as a support to the development of non-small cell lung cancer skeletal metastases.We set up an in vivo ...
Charlotte Cohen, Emilie Goguet, Julie Antomarchi, Rasha Al-Sahlanee, Julien Cherfils-Vicini, Nicolas Glaichenhaus, Thierry Balaguer, Damien Ambrosetti, Marie-Ange Millet, Babou Karimdjee Soilihi, Nicolas Amoretti, Heidy Schmid-Antomarchi, Annie Schmid-Alliana   +12 more
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Chemokine CX3CL1 has potential anti-fibrosis effect in mouse liver fibrosis [PDF]

Jichu yixue yu linchuang, 2023
Objective To explore the effect and mechanism of chemokine CX3CL1 on mouse liver fibrosis model. Methods C57BL/6 mice were randomly divided into CCl-4 model group and normal control group with 8 animals in each group. The model group was injected with 10%
CHENG Qi, LI Ning, YU Kangkang, SHI Guangfeng
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