Results 31 to 40 of about 17,635 (197)

Targeted inhibition of CX3CL1 limits podocytes ferroptosis to ameliorate cisplatin-induced acute kidney injury

Molecular Medicine, 2023
Background It is widely acknowledged that cisplatin-induced nephrotoxicity hinders its efficacy during clinical therapy. Effective pharmaceutical interventions for cisplatin-induced acute kidney injury (Cis-AKI) are currently lacking.
Qiming Gong, Teng-fang Lai, Liudan Liang, Yan Jiang, Fahui Liu   +4 more
semanticscholar   +1 more source

Fractalkine (CX3CL1), GM‐CSF and VEGF‐a levels are reduced by statins in adult patients

Clinical and Translational Medicine, 2014
Background Fractalkine (CX3CL1) promotes migration and adhesion of lymphocytes and monocytes to inflamed tissues. Prior studies show a role for CX3CL1 in atherosclerosis.
Thomas R Cimato, Beth A Palka
doaj   +1 more source

CX3CL1(+) Microparticles-Induced MFG-E8 Enhances Apoptotic Cell Clearance by Alveolar Macrophages

Cells, 2021
During the resolution phase of acute lung injury, apoptotic cells release CX3CL1 as a “find-me” signal to attract alveolar macrophage transmigration toward apoptotic cells for phagocytosis. However, it is still not clear whether CX3CL1 has pro-phagocytic
Wen-Hui Tsai, Shao-Chi Chang, Yu-Chieh Lin, Hui-Chi Hsu   +3 more
doaj   +1 more source

CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting

Frontiers in Cellular Neuroscience, 2023
Introduction Hypoxia-induced neuronal damage is the primary cause of cognitive impairment induced by high-altitude exposure. Microglia play a crucial regulatory role in the central nervous system (CNS) homeostasis and synaptic plasticity.
Xueting Wang, Yuqi Xie, Yun Niu, Baolan Wan, Yapeng Lu, Qian-qian Luo, Li Zhu   +6 more
semanticscholar   +1 more source

The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances response to anti-PD-1 immunotherapy

Frontiers in Immunology, 2023
CX3CL1 secreted in the tumor microenvironment serves as a chemoattractant playing a critical role in metastasis of CX3CR1 expressing cancer cells. CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migration ...
A. Chaudhri, Xia Bu, Yunfei Wang, Michael Gomez, James A. Torchia, Ping Hua, Shao-Hsi Hung, M. Davies, G. Lizée, Ulrich H. von Andrian, Patrick Hwu, G. Freeman   +11 more
semanticscholar   +1 more source

Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice

Journal of Neuroinflammation, 2020
Background Fractalkine (CX3CL1; FKN) is a chemokine expressed by neurons that mediates communication between neurons and microglia. By regulating microglial activity, CX3CL1 can mitigate the damaging effects of chronic microglial inflammation within the ...
Aimee N. Winter, Meena S. Subbarayan, Bethany Grimmig, Jason A. Weesner, Lauren Moss, Melinda Peters, Edwin Weeber, Kevin Nash, Paula C. Bickford   +8 more
doaj   +1 more source

Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus

Frontiers in Cell and Developmental Biology, 2023
Diabetes-related pathophysiological alterations and various female reproductive difficulties were common in pregnant women with gestational diabetes mellitus (GDM), who had 21.1 million live births.
Amin Ullah, Jing Zhao, Rajeev K. Singla, Bairong Shen   +3 more
semanticscholar   +1 more source

CX3CL1 (fractalkine) protein expression in normal and degenerating mouse retina: in vivo studies.

PLoS ONE, 2014
We aimed to investigate fractalkine (CX3CL1) protein expression in wild type (wt) retina and its alterations during retinal degeneration in mouse model (rd10) of retinitis pigmentosa.
Marina Zieger, Peter K Ahnelt, Pavel Uhrin   +2 more
doaj   +1 more source

Metabolic‐Immune Suppression Mediated by the SIRT1‐CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma

Advancement of science
Metabolic reprogramming of tumor cells dynamically reshapes the distribution of nutrients and signals in the tumor microenvironment (TME), affecting intercellular interactions and resulting in metabolic immune suppression.
Ruiyang Zi, Xiang Zhao, Limei Liu, Yijie Wang, Rui Zhang, Zhiheng Bian, Haoran Jiang, Taorui Liu, Yixin Sun, Han Peng, Xuesong Wang, Fanghao Lu, Chao Zhang, Fan Zhang, Qing Qin, Houjie Liang, Jianjun Li, Zhihao Wei, Yan Dong   +18 more
semanticscholar   +1 more source

Fractalkine Signalling (CX3CL1/CX3CR1 Axis) as an Emerging Target in Coronary Artery Disease

Journal of Clinical Medicine, 2023
Acute myocardial infarction (MI) is the most common and dramatic complication of atherosclerosis, which, despite successful reperfusion therapy, can lead to incident heart failure (HF).
S. Loh, Y. Ekinci, L. Spray, Visvesh Jeyalan, T. Olin, G. Richardson, D. Austin, Mohammad Alkhalil, I. Spyridopoulos   +8 more
semanticscholar   +1 more source