Results 41 to 50 of about 17,635 (197)

CX3CL1 (Fractalkine)-CX3CR1 Axis in Inflammation-Induced Angiogenesis and Tumorigenesis

International Journal of Molecular Sciences
The chemotactic cytokine fractalkine (FKN, chemokine CX3CL1) has unique properties resulting from the combination of chemoattractants and adhesion molecules.
D. Szukiewicz
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The Cytokine CX3CL1 and ADAMs/MMPs in Concerted Cross-Talk Influencing Neurodegenerative Diseases

International Journal of Molecular Sciences, 2023
Neuroinflammation plays a fundamental role in the development and progression of neurodegenerative diseases. It could therefore be said that neuroinflammation in neurodegenerative pathologies is not a consequence but a cause of them and could represent a
Matilda Iemmolo, G. Ghersi, G. Bivona
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Fractalkine (CX3CL1), a new factor protecting β-cells against TNFα

Molecular Metabolism, 2014
Objective: We have previously shown the existence of a muscle–pancreas intercommunication axis in which CX3CL1 (fractalkine), a CX3C chemokine produced by skeletal muscle cells, could be implicated.
Sabine Rutti, Caroline Arous, Domitille Schvartz, Katharina Timper, Jean-Charles Sanchez, Emmanouil Dermitzakis, Marc Y. Donath, Philippe A. Halban, Karim Bouzakri   +8 more
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LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress

Cell Death and Disease
According to the World Health Organization, more than 12% of the world’s population suffers from noise-induced hearing loss (NIHL). Oxidative stress-mediated damage to the stria vascularis (SV) is one of the pathogenic mechanisms of NIHL.
Ying Yi, Min-Yu Wu, Kai-Tian Chen, An-Hai Chen, Lin-Qiu Li, Qin Xiong, Xian-ren Wang, W. Lei, Guan-Xia Xiong, Shu-Bin Fang   +9 more
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Hypothalamic FTO promotes high-fat diet-induced leptin resistance in mice through increasing CX3CL1 expression.

Journal of Nutritional Biochemistry, 2023
Long-term consumption of a high-fat diet (HFD) disrupts energy homeostasis and leads to weight gain. The fat mass and obesity-associated (FTO) gene has been consistently identified to be associated with HFD-induced obesity.
Shujing Liu, Sh. Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, C. Fang, Yuan Wei, F. Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li   +15 more
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CX3CL1 induces cell migration and invasion through ICAM‐1 expression in oral squamous cell carcinoma cells

Journal of Cellular and Molecular Medicine, 2023
Human oral squamous cell carcinoma (OSCC) has been associated with a relatively low survival rate over the years and is characterized by a poor prognosis.
C. Wu, Pei Peng, Ting-Yi Renn, Chia-Jung Lee, Tsung-Ming Chang, Augusta I-Chin Wei, Ju-Fang Liu   +6 more
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Astragaloside IV Alleviates Renal Tubular Epithelial-Mesenchymal Transition via CX3CL1-RAF/MEK/ERK Signaling Pathway in Diabetic Kidney Disease

Drug Design, Development and Therapy, 2022
Yonghui Hu,1,2,* Wangna Tang,1,2,* Wenjie Liu,1,2 Zhibo Hu,1,2 Congqing Pan1,2 1NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology ...
Hu Y, Tang W, Liu W, Hu Z, Pan C
doaj  

Lactate/GPR81 recruits regulatory T cells by modulating CX3CL1 to promote immune resistance in a highly glycolytic gastric cancer

Oncoimmunology
Lactate plays an important role in shaping immune tolerance in tumor microenvironment (TME) and correlates with poor prognosis in various solid tumors. Overcoming the immune resistance in an acidic TME may improve the anti-tumor immunity.
Jin Su, Xinyuan Mao, Lingzhi Wang, Zhian Chen, Weisheng Wang, Cuiyin Zhao, Guoxin Li, Weihong Guo, Yanfeng Hu   +8 more
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Research progress on the regulation of autophagy in cardiovascular diseases by chemokines

Open Life Sciences
Cardiovascular diseases (CVD) are the leading cause of death worldwide. Chemokines are a class of proteins that possess characteristics of both chemoattractants and cytokines.
Ma Jingfeng, Tan Xiaotong, Feng Juling, Li Zhihui, Tan Shuo, Li Boling, Zhao Lei   +6 more
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YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment

Molecular Cancer
Peritumoral hepatocytes are critical components of the liver cancer microenvironment, However, the role of peritumoral hepatocytes in the local tumor immune interface and the underlying molecular mechanisms have not been elucidated.
Zhenyu Yang, Xin Wang, Yizhen Fu, Weijie Wu, Zili Hu, Qingyang Lin, Wei Peng, Yangxun Pan, Juncheng Wang, Jinbin Chen, Dandan Hu, Zhongguo Zhou, Li Xu, Yaojun Zhang, Jiajie Hou, Minshan Chen   +15 more
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