Structure basis for the modulation of CXC chemokine receptor 3 by antagonist AMG487. [PDF]
Cell Discov, 2023 Jiao H +6 more
europepmc +1 more source
Evidence for a Two‐Step Model for Activation of GPR25 by the Chemoattractant CXCL17
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.ABSTRACT CXCL17 was recently reported to activate GPR25, a receptor expressed by T‐regulatory cells. Although classified as a chemokine, the activity of CXCL17 is ablated by minor C‐terminal truncation, suggesting a novel mode of receptor activation. We set out to test this hypothesis by mutagenesis. GPR25 was expressed in the murine pre‐B cell line L1.
Wuqing Yang +2 more
wiley +1 more source
Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies
, 2009 The use of neutralizing antibodies is one of the most successful methods to interfere with receptor–ligand interactions in vivo. In particular blockade of soluble inflammatory mediators or their corresponding cellular receptors was proven an effective ...
Christen, Urs +2 more
core +1 more source
Structural basis of CXC chemokine receptor 1 ligand binding and activation. [PDF]
Nat Commun, 2023 Ishimoto N +8 more
europepmc +1 more source
Type I and II Interferon Signalling Characterizes the Transcriptional Landscape of Sweet Syndrome
Experimental Dermatology, Volume 35, Issue 7, July 2026.ABSTRACT Sweet syndrome (SS) is an autoinflammatory neutrophilic dermatosis characterized by abrupt‐onset inflammatory skin lesions and systemic symptoms, yet its molecular pathogenesis remains incompletely defined. To delineate disease‐specific inflammatory programmes, we performed NanoString‐based transcriptomic analysis of SS skin lesions and ...
Laura Calabrese +12 more
wiley +1 more source
ELR CXC chemokine expression in benign and malignant colorectal conditions-8
, 2011 < 0.05, ** < 0.001, = 30 and 48, respectively. Fold increase above 1 indicates chemokine overexpression in CRA and CRC tissues related to unaffected neighbor tissues, respectively.Copyright information:Taken from "ELR+ CXC chemokine expression in benign ...
Claudia Rubie (55165) +7 more
core +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
ELR CXC chemokine expression in benign and malignant colorectal conditions-0
, 2011 < 0.05, ** < 0.001, = 30 and 48, respectively. Fold increase above 1 indicates chemokine overexpression in CRA and CRC tissues related to unaffected neighbor tissues, respectively.Copyright information:Taken from "ELR+ CXC chemokine expression in benign ...
Claudia Rubie (55165) +7 more
core +1 more source
Tzu Chi Medical JournalChemokines are small, secreted cytokines crucial in the regulation of a variety of cell functions. The binding of chemokine C-X-C motif chemokine ligand 12 (CXCL12) (stromal cell-derived factor 1) to a G-protein-coupled receptor C-X-C chemokine receptor ...
Jui-Hung Yen +5 more
doaj +1 more source
CXC chemokine ligand 4 (CXCL4) down-regulates CC chemokine receptor expression on human monocytes
, 2010 During acute inflammation, monocytes are essential in abolishing invading micro-organisms and encouraging wound healing. Recruitment by CC chemokines is an important step in targeting monocytes to the inflamed tissue. However, cell surface expression of
Ernst Brandt +3 more
core +1 more source