Results 151 to 160 of about 62,416 (259)

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Modulation of chemokine secretion and oxidative stress <i>in vitro</i> in thyroid cells after exposure to thiocyanate, nitrate, or perchlorate. [PDF]

Front Endocrinol (Lausanne)
Greco A, Coperchini F, Franchi E, Denegri M, Croce L, Teliti M, Marotta V, Magri F, De Marco G, Ferrarini E, Pignata L, Agretti P, Tonacchera M, Rotondi M.   +13 more
europepmc   +1 more source

613 Evaluation of CXCL10 chemokine in vitiligo [PDF]

Journal of Investigative Dermatology, 2016
M. El-Domyati, W. Hosam El-Din, A.F. Rezk, J. Uitto, O. Igoucheva, J. Lee, M. Farber, V. Alexeev   +7 more
openaire   +1 more source

A STAT1/ETC/GBP1 axis represents a potential therapeutic target for noncommunicable granulomatous skin disease. [PDF]

Sci Adv
Huerta Arana M, Klapproth H, Stanczak MA, Bopp L, Witschurke K, Seitz R, Lopéz Martinez M, Zamek J, Henschke S, Rana N, O'Sullivan D, Steinkamp J, Lackmann JW, Damsky W, von Stebut E, Sanin DE, Zigrino P, Klein Geltink RI, Pearce EJ, Pearce EL, Fabri M.   +20 more
europepmc   +1 more source

Differential Roles for IL‐4Rα and IL‐13Rα1 in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis

Allergy, EarlyView.
This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.
Anish Dsilva, Shraddha Sharma, Shireen Barakey, Ariel Wagner, Alice Keisar, Tali Bar‐on, Michal Itan, Ariel Munitz   +7 more
wiley   +1 more source

LncRNA AFAP1-AS1 mediates therapy-dependent expression of CCL5, CXCL10 and MMP9 in multiple sclerosis. [PDF]

Biochem Biophys Rep
Hegazy LN, Elkhodiry AA, Rashad MH, Moustafa RR, El Tayebi HM.   +4 more
europepmc   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Microvascular endothelial scavenger receptor class B type I protects against heart failure with preserved ejection fraction by inhibiting T-cell cardiotropism. [PDF]

EMBO Mol Med
Wu Y, Yang X, Bai Y, Li C, Wang P, Xu Q, Li H, Rao X, Xu Y, Chen J, Cao H, Zhang Q, Zhao M, Zhan R, Fan X, Hou Y, Liu J, Lu HS, Wang T, Gao WD, Huang L, Xiao H, Zu L, Daugherty A, Xu M, Zheng L.   +25 more
europepmc   +1 more source

Dry eye disease symptoms and associated risk factors in a Norwegian clinical cohort

Acta Ophthalmologica, EarlyView.
Abstract Background The relationship between dry eye disease (DED) symptoms and different demographic, clinical and lifestyle factors remains poorly understood. Norway's cold climate and dry indoor air may accelerate tear evaporation, contributing to a very high meibomian gland dysfunction prevalence, as found in multiple studies.
Mazyar Yazdani, Fredrik A. Fineide, Reza A. Badian, Ayyad Zartasht Khan, Helge Rootwelt, Jan Terje Kvaløy, Tor Paaske Utheim   +6 more
wiley   +1 more source

Diagnostic Potential of Urine CXCL10 and Donor-Derived cfDNA in Kidney Transplant Rejection. [PDF]

Transpl Int
Fantus D, Balshaw R, Saw CL, Belkaid M, Tangprasertchai NS, Viard T, Gougeon F, Belair J, Daniel C, Lamarche C, Casas S, Cardinal H, Ho J.   +12 more
europepmc   +1 more source