Results 81 to 90 of about 28,744 (150)

Whole Blood Transcriptomic Response to Perioperative Dexamethasone in Total Knee Arthroplasty: A Targeted Panel Analysis

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Changes in the transcriptome of immune cells are predictive of clinical outcomes. These effects may be surgery‐specific and possibly modulated by glucocorticoids. We investigated the immune response and the impact of dexamethasone on the response in patients undergoing total knee arthroplasty (TKA). Methods The transcript levels (n =
Asger Krog Mølgaard, Kasper Smidt Gasbjerg, Lukas Balsevicius, Britt Cappelen, Adile Orhan, Helin Yikilmaz Pardes, Ole Mathiesen, Thomas Litman, Daniel Hägi‐Pedersen, Ismail Gögenur   +9 more
wiley   +1 more source

Astrocyte-derived CXCL10 exacerbates endothelial cells pyroptosis and blood–brain barrier disruption via CXCR3/cGAS/AIM2 pathway after intracerebral hemorrhage

Cell Death Discovery
Intracerebral hemorrhage (ICH) is a devastating disease that disrupts the blood–brain barrier (BBB), triggers inflammation, and leads to subsequent neurological deficits.
Wenqianjun Sheng, Zhangyi Wu, Jingyan Wei, Jun Wang, Shengfan Zhang, Zhiquan Ding, Jinhao Zhong, Dexian Deng, Zhenzhong Zhong, Yunong Yin, Yulong Li, Qinghua Wang   +11 more
doaj   +1 more source

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer

Immunology, Volume 178, Issue 3, Page 377-386, July 2026.
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros, Gabriel Augusto Leite, Arthur Gomes de Andrade, Maria Danielma dos Santos Reis, Luiz Henrique Agra Cavalcante‐Silva, Marvin Paulo Lins   +5 more
wiley   +1 more source

Engineered CXCR3-A expression enhances B7-H3-targeting CAR T cell migration and efficacy against diffuse intrinsic pontine glioma

Nature Communications
Diffuse intrinsic pontine glioma (DIPG) is a fatal brainstem tumor desperately in need of better treatments. Chimeric antigen receptor (CAR) T cell therapies for DIPG have demonstrated clinical tolerability and bioactivity, but not universal benefit.
Edward Z. Song, Andrea Timpanaro, Michael Meechan, Leonel Elena-Sanchez, Lucy Z. Li, Sophie Jamet, Davina S. Lau, Lily I. Winter, Matthew D. Dun, Jessica B. Foster, Myron K. Evans, Siobhan S. Pattwell, Vandana Kalia, Surojit Sarkar, Michael C. Jensen, Matthew C. Biery, Nicholas A. Vitanza   +16 more
doaj   +1 more source

Prolonged ruxolitinib cream treatment for vitiligo among patients with no or limited response in the first 6 months

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Albert Wolkerstorfer, Melinda J. Gooderham, Michael Sebastian, David Rosmarin, Andrew Blauvelt, Maryam Shayesteh Alam, Jacek Zdybski, Shaoceng Wei, Deanna Kornacki, Thierry Passeron, John E. Harris   +10 more
wiley   +1 more source

The metastatic role of the CXCL10-CXCR3 axis and its therapeutic potential in osteosarcoma

Journal of Bone Oncology
The CXCL10-CXCR3 axis regulates immunity, tumorigenesis, and metastasis in multiple cancers. Yet, its roles in osteosarcoma (OS), the predominant pediatric malignant bone tumor, are not fully defined.
Benjamin B. Gyau, Junyan Wang, Xiang Chen, Margaret A. Clement, Zoe D. Man, Angela M. Major, Mathew C. Weiser, Jun Xu, John Hicks, Tsz-Kwong Man   +9 more
doaj   +1 more source

Artemisinin-Related Therapeutic Strategies for Autoimmune Thyroiditis: Chemokine-Receptor Networks, Spatial Thyroid Biology, and Molecular Mechanisms. [PDF]

Drug Des Devel Ther
Sun Y, Yang X, Zhu Q, Yang R.
europepmc   +1 more source

CXCR3 signaling promotes Delta One T cell recruitment and antitumor efficacy in colorectal cancer. [PDF]

J Immunother Cancer
Carreira M, Barros L, Cruz RM, Ferreira C, Costa C, Ferreira CM, Mensurado S, Silva-Santos B, Blanco-Domínguez R.   +8 more
europepmc   +1 more source

G protein-coupled receptor autoantibody expression patterns in adults with decelerated biological aging mirror pediatric profiles. [PDF]

BMC Immunol
Paniskaki K, Stervbo U, Goretzki S, Hufnagel D, Anft M, Heidecke H, Westhoff TH, Rohn H, Felderhoff-Mueser U, Witzke O, Dohna-Schwake C, Babel N.   +11 more
europepmc   +1 more source

CXCL11 secreted by cancer-associated fibroblasts promotes nasopharyngeal carcinoma progression via CXCR3/PD-L1 axis. [PDF]

Cell Adh Migr
Fang J, Cheng H, Zhang P, Wang L.
europepmc   +1 more source