Results 191 to 200 of about 88,749 (308)

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Prognostic value of <i>MYD88</i>/<i>CXCR4</i> mutation allele fraction in Waldenström macroglobulinemia using a multiplex ddPCR assay. [PDF]

Hemasphere
Thanou E, Kollias I, Kalafati E, Vlachos C, Mavrianou-Koutsoukou N, Theologi O, Sakkou M, Liacos C, Taouxi K, Papadimou A, Chrisostomidou K, Papadopoulos A, Gavriatopoulou M, Terpos E, Lianidou E, Dimopoulos MA, Kastritis E, Markou A, Bagratuni T.   +18 more
europepmc   +1 more source

Single Cell Multi‐Omics Revealing the Important Role of MR1 Mediated MAIT Cells in Maintaining Rejection for Liver Transplantation

Cell Proliferation, EarlyView.
This multi‐omics study reveals the significant role of MAIT cells in liver transplant rejection. MAIT cells drive rejection in liver transplantation via the MR1 axis. Their absence reshapes T cell responses and clonal expansion, attenuating allograft injury.
Hailun Cai, Xinqiang Li, Xin Zhou, Xueteng Wang, Zhuoyu Jia, Ruidong Ding, Yurong Luo, Ye Wang, Shipeng Li, Wenxing Sun, Dongxing Wu, Dahong Teng, Kai Zhao, Guanghui Pei, Jinzhen Cai, Bin Wu   +15 more
wiley   +1 more source

Computational Insights into the Activation Mechanism of CXCR4: Implications for the Design of Small Molecule Agonists. [PDF]

J Am Chem Soc
Zhou J, Liu X, Xu Y, Cruz A, An J, Warshel A, Huang Z.   +6 more
europepmc   +1 more source

Hitting the right spot on CXCR4 [PDF]

Nature Reviews Rheumatology, 2019
Mchugh, Jessica, Herbeuval, Jean-Philippe, Smith, Nikaia   +2 more
openaire   +3 more sources

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Endothelial von Hippel-Lindau gene deletion causes abnormal blood and lymphatic vasculature through ectopic activation of the HIF-CXCR4 axis. [PDF]

Development
Li W, Nakayama K, Sato R, Shimada R, Kubota Y, Mukouyama YS.   +5 more
europepmc   +1 more source

_In vivo_ photoacoustic molecular imaging with simultaneous multiple selective targeting using antibody-conjugated gold nanorods

, 2008
The use of gold nanorods for photoacoustic molecular imaging in vivo with simultaneous multiple selective targeting is reported. The extravasation of multiple molecular probes is demonstrated, and used to probe molecular information of cancer cells. This
Ya-Na Wu, Ann-Ann Ding, Churng-Ren Wang, Chen-Wei Wei, Chao-Kang Liao, Pai-Chi Li, Dar-Bin Shieh, Carolina Poe, Suwen Jhan   +8 more
core  

Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia

European Journal of Haematology, EarlyView.
ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco, Diane S. Krause, Sara T. Olalla Saad   +2 more
wiley   +1 more source

Multi-omics reveals a novel Cxcr4⁺ subpopulation of alveolar macrophages and therapeutic effect of AMD3100 in mice with advanced silicosis. [PDF]

Clin Transl Med
Mu M, Li B, Cao H, Zou Y, Yan R, Wang F, Zhao Y, Xie Z, Du M, Wu X, Tao X, Wang J.   +11 more
europepmc   +1 more source