Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie, EarlyView.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +2 more sources
Angewandte Chemie, EarlyView.This work focuses on how to improve the selectivity and activity of electrocatalytic CO2 reduction to C3+ products, by the integration of electrocatalyst and electrolyte co‐design. We summarize key C3+ formation mechanisms and provide a comprehensive reaction network through thermodynamic analysis.
Ling Chen, Damien Voiry, Yan Jiao
wiley +2 more sources
Water‐Dispersible Ruthenium Nanocatalyst for Carbonyl Reduction With D2 or T2 in Aqueous Media
Angewandte Chemie, EarlyView.We report the synthesis and characterization of water‐dispersible ruthenium nanoparticles that catalyze the reductive deuteration and tritiation of carbonyl compounds in aqueous media, enabling efficient access to a broad range of isotopically labeled polar molecules, including cyclic peptides, antibody‐drug conjugate linkers, pegylated derivatives ...
Elisa Martinelli +6 more
wiley +2 more sources
Cobalt‐Catalyzed Radical Ligand Transfer (RLT) Enables Remote‐Markovnikov Hydroamination of Alkenes
Angewandte Chemie, EarlyView.A cobalt‐catalyzed remote‐Markovnikov 1,3‐hydroamination of allyl carboxylates proceeds through MHAT, 1,2‐radical acyloxy migration (1,2‐RAM), and radical ligand transfer (RLT) from a Co‐N intermediate, providing protected amino alcohols. ABSTRACT Amino alcohols are prevalent in pharmaceuticals, agrochemicals, and functional materials, yet ...
Arman Khosravi +7 more
wiley +2 more sources
Glutathione‐Responsive Acyl‐Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis
Angewandte Chemie, EarlyView.The self‐immolation of disulfide‐based mRNA modifications in response to endogenous glutathione (GSH) promotes a gradual release of translatable mRNA within the cell, leading to improved nuclease resistance, tunable release properties, and a significant increase (up to 600%) of target protein production over time. This strategy offers an exciting proof
Mary E. Flood +6 more
wiley +2 more sources
Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol
Angewandte Chemie, EarlyView.A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley +2 more sources
Sustainable Pd‐Catalyzed Aminations “on Dirty Water”
Angewandte Chemie, EarlyView.Aminations, done safely yet neat, and therefore, quickly, using low levels of Pd, in “dirty water” that must contain 30% KOH; not NaOH, and not at 5%,10%, 20%, 40%, or 50% KOH. Moreover, no base sensitivity of functional groups! Very cool. Thank you, Nature.
Erfan Oftadeh +4 more
wiley +2 more sources
Rapidly Diversifying Hydrogen‐Bonded Organic Frameworks With Permanent Porosity
Angewandte Chemie, EarlyView.This article reviews diversifying hydrogen‐bonded organic frameworks (HOFs) with permanent porosity reported over the past 15 years, based on the molecular structures of their constituent tectons. Furthermore, several distinctive aspects and concepts are described, such as permanent porosity, isostructural (isoreticular) HOFs, and multicomponent mixed ...
Taito Hashimoto, Ichiro Hisaki
wiley +2 more sources
Advancements in fire-related toxic gas detection and prophylactic strategies: A focus on cyanide concentration analysis and antidote efficacy in controlled smoke inhalation models. [PDF]
PLoS OneTani J +7 more
europepmc +1 more source
Candidate Cyanide Resistance Genes in Eutardigrade (Tardigrada) Genomes and KCN Resistance of <i>Hypsibius exemplaris</i>. [PDF]
Int J Mol SciBartylak T +3 more
europepmc +1 more source