Results 111 to 120 of about 123,303 (240)

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Phytoremediation of Mercury and Cyanide Contaminated Soils by Physic Nut (Jatropha curcas L.) and Citronella Grass (Cymbopogon nardus)

Jurnal Ilmu Lingkungan
Mercury and cyanide are compounds that have the potential to pollute the environment, both of which are found in the tailing waste of artisanal and small-scale gold mining (ASGM).
A. Silvan Erusani, Nurmaya Arofah, Fabika Azahra, Nurhasni Nurhasni, Titik Inayah   +4 more
doaj   +1 more source

Unlocking Li/Mg‐Based Photochemical Nitration Platforms for Anticancer Drug Discovery

Advanced Science, EarlyView.
Two low‐toxicity light main‐group metal photochemical systems based on lithium and magnesium are constructed for selective C(sp2)‐H (di)nitration of anilines. The obtained dinitrated products exhibit anti‐HCC (hepatocellular carcinoma) and anti‐KYSE30 cell activities, holding promise as novel antitumor candidates.
Qian Wan, Jiali Zhu, Shanshuo Liu, Luchuan Ou, Huizhen Wang, Yu Lan, Zhou Dong, Yihang Bai, Wei Yang, Shihan Liu, Yan Qiao, Shi‐Jun Li, Zhigang Ren, Linbin Niu   +13 more
wiley   +1 more source

MpaR-driven expression of an orphan terminal oxidase subunit supports Pseudomonas aeruginosa biofilm respiration and development during cyanogenesis

mBio
Pseudomonas aeruginosa is a common, biofilm-forming pathogen that exhibits complex pathways of redox metabolism. It produces four different types of terminal oxidases for aerobic respiration, and for one of these, the cbb3-type terminal oxidases, it has ...
Marina K. Smiley, Doran C. Sekaran, Farhad Forouhar, Erica Wolin, Marko Jovanovic, Alexa Price-Whelan, Lars E. P. Dietrich   +6 more
doaj   +1 more source

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

Enhanced Photocatalytic Degradation of Cyanide in Mining Wastewater Using a ZnO-BiOI Heterojunction Catalyst

Surfaces
The mining industry often relies on the natural degradation of tailings dams to break down cyanide in wastewater. However, this method has drawbacks, including high costs due to significant water demand and variable effectiveness dependent on ...
Darlington C. Ashiegbu, Paballo Pilane, John Moma, Herman Potgieter   +3 more
doaj   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Cyanide-Limited Complexation of Molybdenum(III): Synthesis of Octahedral [Mo(CN)₆]^3- and Cyano-Bridged [Mo₂(CN)₁₁]^5-

, 2016
Octahedral coordination of molybdenum(III) is achieved by limiting the amount of cyanide available upon complex formation. Reaction of Mo(CF3SO3)3 with LiCN in DMF affords Li3[Mo(CN)6]·6DMF (1), featuring the previously unknown octahedral complex [Mo(CN ...
Jeffrey R. Long (1341528), Laurance G. Beauvais (2505370)   +1 more
core   +1 more source