Results 171 to 180 of about 7,042 (282)

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Decoupling Cyanide Activation from C-C Bond Formation in Ni-Catalyzed Cyanation of Strained Ketones Using Benzonitriles. [PDF]

J Am Chem Soc
Coddington NJ, Bradley RD, Luna YA, Loper MD, Saucedo PJ, Ouyang R, Lo WL, Carta V, Bahamonde A.   +8 more
europepmc   +1 more source

Removal of cyanides from water by air oxidation in a cocurrent downflow fixed bed reactor

, 2002
A method for removal of cyanides from water is described. The method involves the air oxidation of cyanides in a fixed bed reactor with cocurrent downflow.
Murathan, ATİLLA MİRATİ, Komurcu, M, Alicilar, A, Ar, I   +3 more
core  

Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome

Annals of Neurology, EarlyView.
Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca, Adrià Vilaseca‐Capel, Judith Cantó‐Santos, Ester Tobías, Félix Andújar‐Sánchez, Laia Farré‐Tarrats, Frederic Tort, Carles Rentero, Carlos Enrich, Virginia López, Juan R. Tejedor, Anna Esteve‐Codina, Cristina Núñez de Arenas, Pedro J. Moreno‐Lozano, José C. Milisenda, Mar O'Callaghan, Teresa García‐Silva, Montserrat Morales‐Conejo, Mario F. Fraga, Rafael Artuch, Miguel Á. Martín, José M. Cuezva, Ana Matas, Glòria Garrabou, Mariona Guitart‐Mampel   +24 more
wiley   +1 more source

In situ deep-sea surface-enhanced Raman scattering sensor reveals cyanide as a key factor in cold seep nitrogen cycling. [PDF]

Sci Adv
Wang S, Zhao T, He W, Li F, Wang Z, Pan R, Li L, Xi S, Luan Z, Zhang Z, Li B, Chen L, Zhang X.   +12 more
europepmc   +1 more source

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

A Two-In-One Versatile Colorimetric Sensor for Cyanide Anion and Volatile Amines Based on 1‑Hydroxyanthraquinone with Electron-Withdrawing Groups. [PDF]

ACS Omega
Martyanov TP, Kudrevatykh AA, Mudrykh MA, Musaev ME, Korchagin DV, Sulimenkov IV, Ushakov EN, Klimenko LS.   +7 more
europepmc   +1 more source

Cyanid [PDF]

, 2018
C. Vidal, W.-R. Külpmann
openaire   +2 more sources

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Advancements in fire-related toxic gas detection and prophylactic strategies: A focus on cyanide concentration analysis and antidote efficacy in controlled smoke inhalation models. [PDF]

PLoS One
Tani J, Chen JL, Liao WC, Chen CH, Wang CH, Sun TH, Shiue YL, Tsai JW.   +7 more
europepmc   +1 more source