Results 51 to 60 of about 14,455 (283)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Possibilities of correcting iatrogenic mucositis with cyanides in experiment

Russian Open Medical Journal, 2020
Background — Radiation and chemotherapy of cancer cause complications that drastically reduce the quality of life. This requires the search for effective therapeutic agents for the mucositis treatment.
Kristina A. Arakelyan, Inessa G. Romanenko, Elena P. Golubinskaya, Evgeniya Yu. Zyablitskaya, Tatyana P. Makalish   +4 more
doaj   +1 more source

EFFECTS OF DRYING AND ENSILING METHODS ON CYANIDES CONTENTS AND CHEMICAL COMPONENTS OF CASSAVA ROOTS AND STEMS [PDF]

, 2008
The objectives of this experiment was to compare the drying and ensiling methods to reduce cyanides contents in cassava, as well as related nutrient components.
Achmadi, Joelal, Kawamoto, Y, Mizumachi, S, Purnomoadi, A, Rahmi, B, Yanti, Y   +5 more
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Copper–cobalt double metal cyanides as green catalysts for phosphoramidate synthesis

Communications Chemistry, 2023
Phosphoramidates are common and widespread backbones of a great variety of fine chemicals, pharmaceuticals, additives and natural products. Conventional approaches to their synthesis make use of toxic chlorinated reagents and intermediates, which are ...
Alejandro Fonseca, Aram L. Bugaev, Anna Yu. Pnevskaya, Kwinten Janssens, Carlos Marquez, Dirk De Vos   +5 more
doaj   +1 more source

Statutory, legal, scientific and productive aspects of conditions and prospects of development of antidote therapy in the Russian Federation

Вестник войск РХБ защиты, 2023
The modern period in the development of the world community and the Russian Federation in particular is characterized by the globalization of chemical danger.
V. D. Gladkikh, М. М. Muradov, N. А. Kolosova, I. К. Kasatkin, L. М. Slastilova   +4 more
doaj   +1 more source

The spectroscopic parameters of sodium cyanide, NaCN (X 1A'), revisited

, 2019
The study of the rotational spectrum of NaCN (X $^1$A') has recently been extended in frequency and in quantum numbers. Difficulties have been encountered in fitting the transition frequencies within experimental uncertainties.
Cohen, D.T. Halfen, Halfen, He, Holger S.P. Müller, Kawaguchi, L.M. Ziurys, Müller, Müller, Müller, Müller, Müller, Pickett, Turner, van Vaals, van Vaals   +15 more
core   +1 more source

Thermodeformational Behavior of Cubic Crystals of Sodium Cyanide [PDF]

, 2016
In the paper the authors provide results of the study of anisotropic and isotropic acoustic (elastic waves propagation velocities), dimensional (elastic moduli) and nondimensional (Poisson's ratios) elastic characteristics of mono- and polycrystals of ...
Gil, Ludmila Boleslavna, Solovyan, A. V., Tesleva, Elena Pavlovna   +2 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Utilization of flotation in copper extraction from polymetallic ore [PDF]

, 2020
The aim of this study was to examineflotation of utility metals from poor polymetallic ores and verify the potential for profitable yields in connection withpotentially economic deposits of non-ferrous metals.The paper describes results in ...
Janáková, Iva, Vrlíková, Věra, Čablík, Vladimír   +2 more
core   +1 more source