Results 71 to 80 of about 6,212 (279)

2,6-Dibromo-4-chlorophenyl isocyanide

IUCrData, 2018
Molecules of the title compound, C7H2Br2ClN (RNC), are bisected by a mirror plane that passes through the chloro and isocyano groups. The isocyano C atom is bisected by two NC...Br contacts, one per Br atom.
Wayland E. Noland, Kenneth J. Tritch
doaj   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Mild Synthesis of Disaccharidic 2,3-Enopyranosyl Cyanides and 2-C-2-Deoxy Pyranosyl Cyanides with Hg(CN)₂/HgBr₂/TMSCN^†

, 2016
Lewis acid-catalyzed dimerization of mono- and disaccharidic per-O-acetylated glycals gave di- and tetrasaccharidic O-acetylated C-glycosides, respectively. 2,3-Enopyranosyl cyanides were obtained from per-O-acetylated glycals by a new, mild anomeric SN‘-
Paul H. Gross (3029922), Andreas H. Franz (3029925), Vyacheslav V. Samoshin (3029916), YiQiu Wei (3029919)   +3 more
core   +1 more source

Combining Fret and Super‐Resolution Microscopy Reveals Kinase Activation and Mitochondrial Activity at the Nanoscale

Advanced Science, EarlyView.
BioSenSRRF is an open‐source workflow that combines conventional FRET biosensors with SRRF reconstruction to generate sub‐diffraction FRET index maps on standard microscopes. The pipeline integrates automated image registration, SRRF reconstruction, quantitative FRET index calculation, and random line‐based hotspot analysis to uncover AURKA‐dependent ...
Nicolas Y. Jolivet, Pierre‐Jean Desmaison, Xavier Pinson, Arthur Masson, Olivier Delalande, Giulia Bertolin   +5 more
wiley   +1 more source

Nickel-Catalyzed Carbocyanation of Alkynes with Allyl Cyanides

, 2016
Allyl cyanides are found to add across alkynes in the presence of a nickel/P(4-CF3−C6H4)3 catalyst to give polysubstituted 2,5-hexadienenitriles with defined stereo- and regiochemistry.
Yasuhiro Hirata (2281873), Natsuko Kashihara (2261398), Yoshiaki Nakao (1522189), Tomoya Yukawa (2357164), Tamejiro Hiyama (2094532)   +4 more
core   +1 more source

Isosteric Substitution Enables Rational Design of Two‐Dimensional Energetic Crystals

Advanced Science, EarlyView.
Isosteric substitution transforms a classical nitro–amine motif into two‐dimensional aminofurazans with performance beyond TATB. ABSTRACT Two‐dimensional (2D) energetic crystals dissipate mechanical insult via interlayer slip, yet their molecular design space remains narrow.
Linyuan Wen, Wentong Tu, Tao Yu, Chao Chen, Zhixiang Zhang, Zhixiang Xie, Yingzhe Liu   +6 more
wiley   +1 more source

ASSESSMENT OF PHYTOCHEMICALS AND ANTIOXIDANT POTENTIAL OF THE STEM BARK OF ALBIZIA CHEVALIERI

The Bioscientist, 2023
Background: Plants produce chemical compounds known as phytochemicals. These phytochemicals have many pharmacological properties which can be harness for the treatment of several diseases.
M. N Eze, H. E Odoh, M. C Apeh
doaj  

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Hydrogen Cyanide Formation on the Analysis of Total Cyanide and Free Cyanide and Improvements of Pretreatment Method of Total Cyanide

BUNSEKI KAGAKU, 2009
シアン化合物は有毒物質であることから，環境及び排水中の全シアンは厳しく規制されている．環境及び排水中の全シアンの分析は，工場排水試験方法（JIS K 0102）に基づいて行われているが，この方法で分析したとき，シアン化合物を使用していない工場及び事業所の排水や廃棄物から全シアンが検出される事例が多数報告されている．本稿では，著者らが既に報告したプリント基板めっき工場，ノーシアン亜鉛めっき工場，カラー写真処理廃液，現像所排水，熱硬化性塗料，アルミニウム合金溶融廃棄物からのシアン化水素（HCN）生成事例と，最近明らかになったアルカリ固定による室温でのシアン化物イオン生成，重油燃焼排ガス洗浄液及び石炭火力発電所排水からのHCN生成事例を紹介し，その生成原因について述べた．また ...
openaire   +2 more sources

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source