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Fluoroacetate and Cyanocobalamin Absorption in the Rat [PDF]
IT has been shown in this laboratory that the administration of fluoroacetate to 3-month-old female rats of the Scott–Russ strain inhibits the absorption of cyanocobalamin1. This was done by tube-feeding each animal with 15 ng 58Co-labelled cyanocobalamin 2 h after it had received an intraperitoneal injection (80 µg/100 g body-wt.) of sodium ...
A. W. Hodson, A.L. Latner
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Cyanocobalamin und Folsäure [PDF]
Folsaure und Vitamin B12 (Cyanocobalamin) sind chemisch nicht verwandte, essentielle Nahrungsbestandteile, die einfachheitshalber gemeinsam besprochen werden sollen, da ein Mangel des einen oder des anderen zu einem morphologisch ahnlichen Stillstand des Knochenmarkswachstums und zu einer Megaloblastenanamie fuhren. Dies ist nicht erstaunlich, da beide
Frederick H. Meyers+2 more
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Mechanism of cyanocobalamin chlorination by hypochlorous acid
JBIC Journal of Biological Inorganic Chemistry, 2021Hypochlorous acid (HOCl) is a strong oxidant produced by myeloperoxidase. Previous work suggested that HOCl modifies the corrin ring of cobalamins to yield chlorinated species via mechanisms that are incompletely understood. Herein, we report a mechanistic study on the reaction between cyanocobalamin (CNCbl, vitamin B12) and HOCl.
Ilia A. Dereven’kov+5 more
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Dependence on Cyanocobalamin Injections
JAMA: The Journal of the American Medical Association, 1989To the Editor. — I started reading the article by Drs Lawhorne and Ringdahl 1 with interest. By the time I finished, I was angry and depressed enough to write this letter. Throughout the article, there was no mention of how vitamin B 12 deficiency can be scientifically assessed for clinical purposes.
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Production of Cyanocobalamine by Azotobacter chroococcum
Zentralblatt für Mikrobiologie, 1984A strain of Azotobacter chroococcum was found to produce a considerable amount of cyanocobalamine especially when cultivated in a medium enriched with 0.3% ammonium chloride. Maximal production of the vitamin was achieved after six days of incubation in static cultures. The organism required molybdenum, iron (Fe++), cobalt and ascorbic acid for optimal
M.A. El-Sayed+5 more
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Journal of the American Pharmaceutical Association (Scientific ed.), 1954
The effect of pH on the stability of solutions of cyanocobalamin and ascorbic acid, alone, and in combinations, is reported. The effect of a contaminant complexing agent at one concentration on aqueous solutions of these vitamins is also reported. The stability of these vitamins, alone, and in combination, in various mixtures of propylene glycol, Sorbo,
Andrew Bartilucci, Noel E. Foss
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The effect of pH on the stability of solutions of cyanocobalamin and ascorbic acid, alone, and in combinations, is reported. The effect of a contaminant complexing agent at one concentration on aqueous solutions of these vitamins is also reported. The stability of these vitamins, alone, and in combination, in various mixtures of propylene glycol, Sorbo,
Andrew Bartilucci, Noel E. Foss
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Photolysis of cyanocobalamin in aqueous solution
Journal of Pharmaceutical and Biomedical Analysis, 1992Cyanocobalamin is photolysed in aqueous solution to produce hydroxocobalamin. The kinetics of photolysis has been studied at pH 1-12 using a newly developed spectrophotometric method for the simultaneous determination of the two compounds at 550 and 525 nm or 361 and 351 nm.
Iqbal Ahmad+2 more
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Oral Crystalline Cyanocobalamin Available
Archives of Internal Medicine, 1981To the Editor. —I read an article in the DecemberArchives(1980;140:1582) concerning the use of liquid cyanocobalamin marketed for intramuscular use. According to Crosby, the injectable cyanocobalamin was used because of the unavailability of an oral form of cyanocobalamin.
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