Results 81 to 90 of about 4,029,048 (318)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A U.S. Carbon Cycle Science Plan [PDF]

open access: yes, 2011
Report assessing the carbon cycle and providing guidance for U.S. researchers. It includes background on the history and context of the carbon cycle and previous science plan as well as chapters describing relevant fundamental science questions, science
Marland, Gregg   +4 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Nuclear Fuel Cycle Royal Commission: Tentative findings

open access: yes, 2016
The Tentative Findings of the Nuclear Fuel Cycle Royal Commission are an interim step in the Commission’s process before the completion of the report in May 2016.
Nuclear Fuel Cycle Royal Commission
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Packing Coloring of Some Undirected and Oriented Coronae Graphs

open access: yesDiscussiones Mathematicae Graph Theory, 2017
The packing chromatic number χρ(G) of a graph G is the smallest integer k such that its set of vertices V(G) can be partitioned into k disjoint subsets V1, . . . , Vk, in such a way that every two distinct vertices in Vi are at distance greater than i in
Laïche Daouya   +2 more
doaj   +1 more source

Management, storage and disposal of nuclear and radioactive waste (Issues Paper Four)

open access: yes, 2015
This Nuclear Fuel Cycle Royal Commission Issues Paper looks at the possibility of managing, storing and disposing of nuclear and radioactive waste in South Australia, and examines the risks and opportunities of doing ...
Nuclear Fuel Cycle Royal Commission
core  

MEK1/2 regulates microtubule organization, spindle pole tethering and asymmetric division during mouse oocyte meiotic maturation

open access: yes, 2007
It is well known that MAPK plays pivotal roles in oocyte maturation, but the function of MEK (MAPK kinase) remains unknown. We have studied the expression, subcellular localization and functional roles of MEK during meiotic maturation of mouse oocytes ...
Bo Xiong   +32 more
core   +1 more source

Transferring life cycle engineering to surface engineering

open access: yes, 2022
S.557-562Most surface finishing processes for metals are associated with a high energy demand and the use of chemicals with the potential impact on human- and eco-toxicity.
Thiede, Sebastian   +4 more
core   +1 more source

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