Results 211 to 220 of about 16,264 (303)

Design and application of cyclic-di-GMP biosensors.

, 2013
Cyclic‐di‐GMP is an important bacterial secondary messenger molecule that regulates motility, virulence and biofilm formation in many pathogenic bacteria. This messenger molecule is synthesized from cellular GTP by diguanylate cyclase (DGC) and hydrolyzed by phosphodiesterases (PDE) to form 5‐pGpG and GMP.
openaire   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Cyclic-di-GMP signalling mutants drive ecological succession and self-generated diversity in experimentally evolved biofilms of <i>Pseudomonas aeruginosa</i>. [PDF]

Microbiology (Reading)
Wickham GJ, Zhang C, Sweet R, Solsona-Gaya M, Webber MA.   +4 more
europepmc   +1 more source

Genome characterization of a uropathogenic <i>Pseudomonas aeruginosa</i> isolate PA_HN002 with cyclic di-GMP-dependent hyper-biofilm production. [PDF]

Front Cell Infect Microbiol, 2022
Lin S, Chen S, Li L, Cao H, Li T, Hu M, Liao L, Zhang LH, Xu Z.   +8 more
europepmc   +1 more source

A Case for Anti‐IgE Vaccination

Allergy, EarlyView.
ABSTRACT Immunoglobulin E (IgE) plays a central role in allergic diseases by binding to the high‐affinity receptor FcεRI on mast cells and basophils, where allergen‐induced crosslinking triggers potent inflammatory responses. Various mechanisms by which IgE responses are generated and functionally regulated remain elusive despite many years of research.
Paul Engeroff, Zahra Gharailoo, Monique Vogel, Martin F. Bachmann   +3 more
wiley   +1 more source

Crucial roles of intracellular cyclic di-GMP in impacting the genes important for extracellular electron transfer by <i>Geobacter metallireducens</i>. [PDF]

Appl Environ Microbiol
Jiang Y, Sun L, Hou L, Hu Y, Jiang Z, Dong Y, Song H, Shi L.   +7 more
europepmc   +1 more source

Double take: A dual-functional Hypr GGDEF synthesizes both cyclic di-GMP and cyclic GMP-AMP to control predation in Bdellovibrio bacteriovorus. [PDF]

PLoS Genet, 2022
Rangarajan AA, Waters CM.
europepmc   +1 more source

Molecular characterization and inhibition of cyclic-di-GMP receptor proteins in <i>Pseudomonas aeruginosa</i>: INSIGHTS from docking and dynamics studies. [PDF]

Biochem Biophys Rep
Yakobi SH, Ramaloko W, Maningi NE.
europepmc   +1 more source

Cyclic di-GMP modulates sessile-motile phenotypes and virulence in Dickeya oryzae via two PilZ domain receptors. [PDF]

Mol Plant Pathol, 2022
Chen Y, Lv M, Liang Z, Liu Z, Zhou J, Zhang LH.   +5 more
europepmc   +1 more source

Oligoprogressive renal cell carcinoma: What is the role of surgery?

BJU International, EarlyView.
Objective To provide an overview of the biological mechanism and pattern of oligoprogression in renal cell carcinoma (RCC) and the most updated role of surgery in this setting, highlighting scientific gaps and informing future implications. Methods A non‐systematic search of PubMed/MEDLINE was performed in August 2025 including guidelines, reviews, and
Chiara Re, William H.J. Ince, Leo Bickley, James P. Blackmur, Mouhamad H. Ismail, Justicia Kyeremeh, Teele Kuusk, Eva Mendes Serrao, James O. Jones, Grant D. Stewart   +9 more
wiley   +1 more source