British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu +4 more
wiley +1 more source
Old role with new feature: T2SS ATPase as a cyclic-di-GMP receptor to regulate antibiotic production. [PDF]
Appl Environ MicrobiolLiu H, Xu G, Guo B, Liu F.
europepmc +1 more source
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
PLGA‐particle‐based vaccine induces SARS‐CoV‐2‐specific antibody and T‐cell responses
British Journal of Pharmacology, EarlyView.A novel coronavirus disease 2019 (COVID‐19) vaccine encapsulating recombinant severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike receptor binding domain (RBD) with the double stranded RNA (dsRNA) analogue Riboxxim induces robust systemic and respiratory T‐ and B‐cell responses in mice.
Dennis Horvath +6 more
wiley +1 more source
Cyclic di-GMP inhibits nitrate assimilation by impairing the antitermination function of NasT in Pseudomonas putida. [PDF]
Nucleic Acids ResNie L +9 more
europepmc +1 more source
Advancements in Inorganic Chiral Nanomaterials for Anti‐Tumor Immunotherapy
Cancer Science, EarlyView.Schematic illustration of how inorganic chiral nanomaterials enhance immune activation to promote tumor cell elimination through targeted delivery, immunogenic cell death, and immune microenvironment modulation. ABSTRACT While the past decade has witnessed unprecedented technological advancements, cancer remains a major health threat, with conventional
Siyu Chen +9 more
wiley +1 more source
Intestinal STING‐(Over)activation—A Contributing Factor to Food Allergies?
Allergy, EarlyView.
Sophie Goebel, Hannah Ruth Schiller
wiley +1 more source
Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging
Cancer Science, EarlyView.Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka +4 more
wiley +1 more source
2D Piecewise Linear Scalar Fields with Invertible Integral Lines
Computer Graphics Forum, EarlyView.Abstract Integral lines of the gradient flow are standard features in continuously differentiable scalar fields that enjoy some useful properties: They cover the domain densely, do not split, merge, or intersect, and are therefore invertible. For widely used discretizations of scalar fields, the corresponding polygonal approximations of integral lines ...
T.L. Erxleben +3 more
wiley +1 more source
Informal supply chains of wild meat from rural Amazonia and food security in an urban center
Conservation Biology, EarlyView.Abstract Iquitos, the most populated city in the Peruvian Amazon, is a hub in the regional supply chain of wild meat and supplies urban consumers. Studies on wild meat consumption have focused primarily on markets, limiting the scope of species considered to those that are economically valuable and potential inferences from those data.
Fiorella Briceño Huerta +3 more
wiley +1 more source