Results 251 to 260 of about 16,264 (303)

Hypoxic‐hypocapnic red blood cells in PAGGSM additive solution before and after gamma irradiation show improved metabolism

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Hypoxic/hypocapnic (HH) treatment and storage conditions have been shown to reduce oxidative stress and improve red blood cell (RBC) quality. This study aimed to validate a good manufacturing practice HH RBC product for obtaining the licence for routine use in patients, by comparison with normoxic RBCs both without ...
Soroth Chey, Jacqueline Maier, Samuel Sowemimo‐Coker, Reinhard Henschler   +3 more
wiley   +1 more source

The therapeutic role of exercise training during menopause for reducing vascular disease

Experimental Physiology, EarlyView.
Abstract Menopause marks a major milestone in female reproductive ageing. It is characterized by the cessation of ovarian function and a concomitant decline in hormones such as oestradiol. Subsequently, females undergoing menopausal transition experience a progressive increase in cardiovascular and cerebrovascular disease risk.
Conan L. H. Shing, Bert Bond, Kerrie L. Moreau, Jeff S. Coombes, Jenna L. Taylor   +4 more
wiley   +1 more source

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling [PDF]

, 2018
Miner, Cathrine A., Miner, Jonathan J., Qian, Wei   +2 more
core   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Post‐exercise ketone supplementation improves endurance performance and mitochondrial adaptations during an 8‐week endurance training intervention

The Journal of Physiology, EarlyView.
Abstract figure legend Twenty‐eight trained males completed 8 weeks of supervised indoor cycling training, receiving post‐exercise and pre‐sleep ketone monoester (KE, n = 14) or isocaloric placebo (CON, n = 14). Both groups improved 30 min time‐trial performance with training, but KE achieved a 4% higher power output than CON at the end of the training
Ruben Robberechts, Youri Bekhuis, Myrthe Stalmans, Wout Lauriks, Martijn Kusters, Karim Taha, Thomas Rosseel, Guido Claessen, Chiel Poffé   +8 more
wiley   +1 more source

What Is the Acheulean?

Evolutionary Anthropology: Issues, News, and Reviews, Volume 35, Issue 2, June 2026.
ABSTRACT The Acheulean represents the longest cultural period known to human history, lasting globally for more than 1.75 million years. It may have emerged as early as 1.95 Ma in Africa, spreading throughout much of the continent and then into Eurasia and lasting up to 350–200 ka in western Europe and South Asia, and even later in eastern Asia ...
Marie‐Helene Moncel, Carolina Cucart‐Mora, Marta Arzarello, Nick Ashton, Javier Baena, Deborah Barsky, Ignacio de la Torre, Nena Galanidou, Paula García‐Medrano, Christine Hertler, Gadi Herzlinger, Thomas Ingicco, Hao Li, Dongdong Ma, Marina Mosquera, Andreu Ollé, Shanti Pappu, Shuwen Pei, Chun Tian, Wei Wang, Christopher J. Bae   +20 more
wiley   +1 more source

Spleen Tyrosine Kinase (SYK) is Necessary for cGAS‐STING Signaling in Müller Glia and Visual Function Deficits in Diabetic Mice

Glia, Volume 74, Issue 6, June 2026.
Hyperglycemic conditions increased mitochondrial membrane permeability and inflammatory signaling in Müller cells via cGAS‐STING activation. SYK was necessary for cGAS–STING activation and increased cytokine expression in Müller cells. Müller glia‐specific SYK deletion reduced glial activation and attenuated inflammatory cytokine expression in the ...
Esma I. Yerlikaya, Siddharth Sunilkumar, Sandeep M. Subrahmanian, Allyson L. Toro, Clay T. Yeager, Kashif A. Shaikh, Edward W. Harhaj, Alistair J. Barber, Michael D. Dennis   +8 more
wiley   +1 more source

Production Performance and Ameliorative Effects of Switchgrass on Severely Saline‐Alkali Land in Coastal Areas of China

GCB Bioenergy, Volume 18, Issue 6, June 2026.
Switchgrass cultivation sustained biomass production while rapidly improving soil structure and reducing salinity in coastal saline‐alkali soils. These changes reshaped microbial communities through environmental filtering, establishing plant‐soil‐microbe feedbacks that support both bioenergy production and ecological restoration.
Aoxiang Chang, Bowen Li, Runli Li, Ting Wu, Qiang Guo, Xincun Hou, Cui Li, Mei Zheng, Honggang Chen, Yu Sun, Jinku Song, Yuejun Ma, Chunqiang Xing, Xiuyun Wan, Jinliang Chen, Chunqiao Zhao, Xifeng Fan, Zhenyu Fan   +17 more
wiley   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source