Results 261 to 270 of about 16,264 (303)

Integrative Analyses Identify a cGAS‐STING Pathway‐Driven Signature With Context‐Dependent Roles in Systemic Lupus Erythematosus

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Zhang et al. identify M7core, a critical cGAS‐STING pathway‐driven gene signature that is activated in most lupus patients’ blood and links to lupus disease severity, lymphopenia, and lupus nephritis. They further reveal the diagnostic and pathogenic characteristics of M7core and emphasize the importance of assessing pathway activity before initiating ...
Lele Zhang, Ming‐Ju Amy Lyu, Ze Hong, Jing Sun, Lan Guo, Jiameng Hu, Munire Maimaiti, Chenhui Li, Jinyi Song, Xiang Zhang, Huansha Yu, Chen Wang, Xuan Wang, Haiyang Hu   +13 more
wiley   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

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The Second Messenger Cyclic Di-GMP

The role of c-di-GMP in the regulatory networks of Escherichia coli., 2010
Table of Contents I. Second Messengers: an Overview 1. Introduction to Second Messengers: Lessons from Cyclic AMP Alan J. Wolfe II. General Principles: the Core 2. Moshe Benziman and the Discovery of Cyclic Di-GMP Dorit Amikam, Haim Weinhouse, and Michael Y. Galperin 3. Ubiquity of Cyclic Di-GMP Pathways: a Bioinformatic Analysis Michael Y. Galperin 4.
Hengge, R. (editors of the book, K. Visick and A. Wolfe), Hengge, R. (editors of the book; K. Visick, A. Wolfe)   +3 more
openaire   +2 more sources

Cyclic di-GMP as a second messenger

Current Opinion in Microbiology, 2006
In many bacteria bis-(3',5')-cyclic dimeric guanosine monophosphate (c-di-GMP) signaling determines the timing and amplitude of complex biological processes from biofilm formation and virulence to photosynthesis. Thereby, the tightly regulated temporal and spatial activity patterns of GGDEF and EAL domain proteins, which synthesize and degrade c-di-GMP,
Ute, Römling, Dorit, Amikam
openaire   +2 more sources

Measuring Individual Cell Cyclic di-GMP: Identifying Population Diversity and Cyclic di-GMP Heterogeneity

2020
Cyclic di-GMP is a second messenger used by bacteria to regulate motility, extracellular polysaccharide production, and the cell cycle. Recent advances in the measurement of real time cyclic di-GMP levels in single cells have uncovered significant dynamic heterogeneity of second messenger concentrations within bacterial populations.
Miller, Samuel I., Petersen, Erik
openaire   +2 more sources

Legionella quorum sensing meets cyclic-di-GMP signaling

Current Opinion in Microbiology, 2020
Bacterial gene regulation occurs through complex networks, wherein linear systems respond to intracellular or extracellular cues and engage on vivid crosstalk. The ubiquitous water-borne bacterium Legionella pneumophila colonizes various distinct environmental niches ranging from biofilms to protozoa, and - as an 'accidental' pathogen - the human lung.
Hochstrasser, Ramon, Hilbi, Hubert
openaire   +3 more sources

Cyclic di-GMP in Burkholderia spp.

2020
Burkholderia spp. survive in diverse ecological niches in association with soil, plants, and animals. In these environments, some members of the Burkholderia spp. participate in beneficial interactions that promote plant growth, nutrient cycling, and bioremediation; however, some Burkholderia spp.
Grace I. Borlee, Mihnea R. Mangalea, Bradley R. Borlee   +2 more
openaire   +1 more source

Cyclic di-GMP as a bacterial second messenger

Microbiology, 2004
Environmental signals trigger changes in the bacterial cell surface, including changes in exopolysaccharides and proteinaceous appendages that ultimately favour bacterial persistence and proliferation. Such adaptations are regulated in diverse bacteria by proteins with GGDEF and EAL domains.
David A, D'Argenio, Samuel I, Miller
openaire   +2 more sources

Noncanonical Cyclic di-GMP Binding Modes

2020
Cyclic diguanosine monophosphate nucleotide (cyclic di-GMP) has emerged as a crucial second messenger molecule that responds to a wide variety of environmental cues in almost all bacteria. Several canonical binding modes of cyclic di-GMP interactions with its protein or riboswitch targets have been described.
Shan-Ho Chou, Michael Y. Galperin
openaire   +1 more source

Mechanisms of Cyclic-di-GMP Signaling in Bacteria

Annual Review of Genetics, 2006
Cyclic-di-GMP is a ubiquitous second messenger in bacteria. The recent discovery that c-di-GMP antagonistically controls motility and virulence of single, planktonic cells on one hand and cell adhesion and persistence of multicellular communities on the other has spurred interest in this regulatory compound.
Jenal, U., Malone, J.
openaire   +2 more sources