Results 271 to 280 of about 9,877,914 (299)
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The structural basis for the sensing and binding of cyclic di-GMP by STING
Nature Structural & Molecular Biology, 2012STING (stimulator of interferon genes) is an essential signaling adaptor that mediates cytokine production in response to microbial invasion by directly sensing bacterial secondary messengers such as the cyclic dinucleotide bis-(3'-5')-cyclic dimeric GMP (c-di-GMP). STING's structure and its binding mechanism to cyclic dinucleotides were unknown.
Yi-He, Huang +4 more
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Cyclic Di-GMP Signaling and Host Immunity
2014Testing the hypothesis that cyclic Di-GMP (c-di-GMP) can be used clinically to inhibit infection, synthetic exogenous c-di-GMP was found not to be bactericidal or bacteriostatic but could significantly inhibit Staphylococcus aureus biofilm formation in vitro.
David K. R. Karaolis +1 more
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Cyclic di-GMP Regulation of Gene Expression
2020Cyclic di-GMP is a nearly ubiquitous bacterial second messenger signaling molecule that links changes in environmental cues to the regulation of a myriad of phenotypes including but not limited to biofilm formation, motility, virulence, and DNA repair.
Meng-Lun Hsieh +2 more
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Methods for Cyclic Di-GMP Detection
2014The first decade of the 21st century has seen an explosion of interest in the bacterial second messenger signal cyclic di-GMP (c-di-GMP). The study of c-di-GMP during this period has been fueled by the development of methods to visualize and quantify this molecule.
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Cyclic di-GMP mediates Mycobacterium tuberculosis dormancy and pathogenecity
Tuberculosis, 2013Dormancy of Mycobacterium tuberculosis is likely to be a major cause of extended chemotherapeutic regimens and wide prevalence of tuberculosis. The molecular mechanisms underlying M. tuberculosis dormancy are not well understood. In this study, single-copy genes responsible for synthesis (dgc) and degradation (pde) of the ubiquitous bacterial second ...
Yuzhi, Hong +5 more
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Cyclic di-GMP and the Regulation of Biofilm Dispersion
2020In nature, bacteria are primarily found as residents of surface-associated communities called biofilms. The formation of biofilms is a cyclical process that is initiated by single planktonic cells attaching to a surface, and comes full cycle when cells disperse from the mature biofilm to resume a planktonic lifestyle.
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Moshe Benziman and the Discovery of Cyclic Di-GMP
2014The story of cyclic dimeric GMP (c-di-GMP), the subject of this chapter, now recognized as a universal bacterial second messenger. A cellulose molecule is a homopolymer of D-glucose residues linked in β-1,4-glucosidic bonds. The nature of the immediate precursor of cellulose, UDP-glucose, has been identified, and the biochemical pathways leading to its
Dorit Amikam +2 more
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2014
This chapter describes the studies that resulted in the experimental verification of the core signaling pathway. It discusses advances in enzymology of c-di-GMP synthesis and hydrolysis, identification and characterization of cyclic di-GMP (c-di-GMP) receptors, end targets, and molecular mechanisms, where these are known. The first line of experimental
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This chapter describes the studies that resulted in the experimental verification of the core signaling pathway. It discusses advances in enzymology of c-di-GMP synthesis and hydrolysis, identification and characterization of cyclic di-GMP (c-di-GMP) receptors, end targets, and molecular mechanisms, where these are known. The first line of experimental
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Cyclic-di-GMP promotes bacteria–host association
Nature Microbiology, 2023Tory A. Hendry, Kelley A. Gallagher
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