Results 181 to 190 of about 121,650 (304)

Senescent Fibroblasts Drive Melanoma Progression Through GCP‐2 Induced CREB Phosphorylation Enhancing Glycolysis

open access: yesAging Cell, EarlyView.
Aging constitutes the largest risk factor for melanoma progression; the underlying reason is poorly understood. Here we show that the chemokine GCP‐2 is excessively released by senescent fibroblasts in vitro and in the skin of old melanoma patients. GCP‐2, via phosphorylation of the transcription factor CREB at serine 133, regulates cell cycle control ...
Abhijit Basu   +15 more
wiley   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

open access: yesAndrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

open access: yesAndrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos   +4 more
wiley   +1 more source

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