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Cyclic adenosine monophosphate in bacteria.
Science (New York, N.Y.), 1970Both cyclic AMP and a specific inducer acting in concert are required for the synthesis of many inducible enzymes in E. coli. Little enzyme is made in the absence of either. In contrast to the specific inducers which stimulate the synthesis only of the proteins required for their metabolism, cyclic AMP controls the synthesis of many proteins.
I, Pastan, R, Perlman
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Stimulation of erythropoiesis by cyclic adenosine monophosphate
Life Sciences, 1971Abstract CYCLIC AMP stimulated the incorporation of radioiron by the red blood cells in polycythemic mice. This effect was potentiated by prior incubation of cyclic AMP with dialyzed rat serum and was partially abolished in vivo , but not in vitro , by anti-erythropoietin.
A S, Gidari, E D, Zanjani, A S, Gordon
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Origin of Cyclic Adenosine Monophosphate in Saliva
Journal of Dental Research, 1975The level of cyclic adenosine monophosphate (AMP) in duct saliva from the dog submandibular gland was increased after cyclic AMP was administered intravenously in vivo. Isoproterenol increased the level of cyclic AMP in plasma and saliva in vivo and in salivary gland slices in vitro, but increased the level only slightly in saliva in a perfused dog ...
T, Hanamori, T, Nagotsu, S, Matsumoto
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Cyclic Adenosine Monophosphate: Function in Photoreceptors
Science, 1971Inactivation of adenylate cyclase in outer segments of retinal photoreceptor cells is proportional to the bleaching of rhodopsin. Membranes of the outer segments also contain a particulate, light-insensitive phosphodiesterase of high specific activity. In electrophysiological experiments, application of cyclic adenosine monophosphate along
W H, Miller, R E, Gorman, M W, Bitensky
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Cyclic adenosine monophosphate and the development of polysphondylium
Journal of Cell Science, 1976ABSTRACT Centre formation in Polysphondylium violaceum is delayed for 2 h on buffered agar containing 10−3 M c-AMP, and for up to 22 h on unbuffered agar with the same c-AMP concentration. With ambient c-AMP concentrations as low as 10−8 M, P. pallidum forms numerous, small, atypical aggregates which do not fruit.
M E, Jones, A, Robertson
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Distribution of Cyclic Adenosine Monophosphate in Rat Brain
Archives of Neurology, 1971Cyclic 3',5'-adenosine monophosphate (AMP) was assayed by converting it enzymatically to adenosine triphosphate (ATP) with phosphodiesterase, myokinase, and pyruvate kinase. Adenosine triphosphate was measured in a liquid scintillation spectrometer from the photons emitted when ATP serves as a substrate of the firefly luciferin-luciferase system.
M S, Ebadi, B, Weiss, E, Costa
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Cyclic Adenosine Monophosphate as a Mediator of Hormone Action
New England Journal of Medicine, 1971ACCORDING to the classic definition, hormones are substances that are secreted by certain tissues and are carried by the circulation to other tissues, where their metabolic effects appear.
G W, Liddle, J G, Hardman
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Cyclic Adenosine Monophosphate and Hypertension in Rats
Science, 1973Aortas from spontaneously hypertensive and stress hypertensive rats contained significantly lower intracellular concentrations of cyclic adenosine monophosphate than did their respective controls. Adenylate cyclase activity was normal but was less responsive to stimulation, while phosphodiesterase activity (especially the low Michaelis-Menten constant ...
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