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The Kinetics of Cyclic ADP-Ribose Formation in Heart Muscle
Biochemical and Biophysical Research Communications, 1995The kinetics of NAD glycohydrolase activity in cardiac muscle homogenates were investigated using HPLC and TLC techniques to identify reaction products. NAD was found to undergo enzymatic hydrolysis yielding ADP-ribose (ADPR) as well as a cyclase reaction resulting in the formation of cyclic ADP-ribose (cADPR).
V, Mészáros, R, Socci, L G, Mészáros
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The CD38/cyclic ADP-ribose system: A topological paradox
The International Journal of Biochemistry & Cell Biology, 1997CD38 was first identified as a lymphocyte differentiation antigen that showed typical properties of an orphan receptor involved in many programs of cell proliferation and activation. However, CD38 proved also to be a bifunctional ectoenzyme that catalyzes the transient formation of cyclic ADP-ribose (cADPR) in a variety of cell types.
DE FLORA, ANTONIO +3 more
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Cyclic ADP-Ribose and Vasomotor Response
2002Vascular smooth muscle (VSM) usually exists in a partially contracted state, from which it can contract further or relax in response to different physiological or pathological stimulations. This contracted state of blood vessels and their contracting and relaxing response to stimuli are often referred to as “vascular tone” and “vasomotor response ...
Pin-Lan Li +2 more
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Cyclic ADP-Ribose and Calcium Signalling
1998It is over 100 years since calcium was first implied as an intracellular regulator in heart by Ringer (1882). Since then its universal role as a regulator has become a cornerstone of cell physiology (Campbell 1983), and much progress has been made in our understanding of cellular calcium homeostasis and the way in which cellular stimuli are transduced ...
A. Galione, H. L. Wilson
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Calcium signaling by cyclic ADP-ribose and NAADP
Cell Biochemistry and Biophysics, 1998Ca2+ mobilization as a signaling mechanism has been placed on center stage with the discovery of the first Ca2+ messenger, inositol trisphosphate (IP3). This article focuses on two new Ca2+ release activators, which mobilize internal Ca2+ stores via mechanisms totally independent of IP3.
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Cyclic ADP-Ribose: Metabolism and Calcium Mobilizing Function
1994Publisher Summary This chapter describes the discovery of cyclic adenosine diphosphate–ribose (cADPR) as a novel endogenous Ca 2+ -mobilizing agent, and the way by which it fulfills most of the criteria necessary for it to be considered a second messenger. The enzymatic pathways for the synthesis and degradation of the metabolite are also summarized.
H C, Lee, A, Galione, T F, Walseth
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Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP
Physiological Reviews, 1997Cells possess various mechanisms for transducing external signals to intracellular responses. The discovery of inositol 1,4,5-trisphosphate (IP3) as a messenger for mobilizing internal Ca2+ stores has centralized Ca2+ mobilization among signaling mechanisms.
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[27] Preparation of cyclic ADP-ribose antagonists and caged cyclic ADP-ribose
1997Timothy F. Walseth +6 more
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Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic
Ca-A Cancer Journal for Clinicians, 2011Johann S de Bono +2 more
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