Results 101 to 110 of about 17,158 (246)

Cyclic ADP-ribose. A new component of calcium signaling.

, 1995
International audienceCyclic ADP-ribose is a recently discovered metabolite of NAD that appears to function in cellular calcium signaling. The discovery that NAD glycohydrolases are bifunctional enzymes that catalyze both the synthesis and hydrolysis of ...
Jacobson, M, Lin, W., Coyle, D, Jacobson, E, Amé, Jean-Christophe   +4 more
core  

Design, Synthesis, and Identification of 4″α-Azidoethyl-cyclic ADP-Carbocyclic-ribose as a Highly Potent Analogue of Cyclic ADP-Ribose, a Ca²⁺-Mobilizing Second Messenger

, 2016
Cyclic adenosine diphosphate-carbocyclic-ribose (cADPcR, 2) is a stable equivalent of cyclic adenosine diphosphate-ribose (cADPR, 1), a Ca2+-mobilizing second messenger.
Takatoshi Sato (1810768), Hayato Fukuda (754042), Satoshi Takano (1574866), Tomoshi Kameda (1368384), Mizuki Watanabe (1874182), Mitsuhiro Arisawa (754043), Satoshi Shuto (102368), Takashi Murayama (171791), Takayoshi Tsuzuki (1574869), Takashi Sakurai (171849)   +9 more
core   +1 more source

CD38-Cyclic ADP-Ribose Signal System in Physiology, Biochemistry, and Pathophysiology. [PDF]

Int J Mol Sci, 2022
Takasawa S.
europepmc   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Methyltransferase-Like 3 Inhibition-Activated cGAS/STING Axis Enhances Immunotherapy and Poly(ADP-Ribose) Polymerase Inhibitor Sensitivity in Lung Adenocarcinoma

Research
The cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING)-mediated type I interferon response plays a crucial role in antitumor immunity, yet the regulatory factors involved in this innate immune response remain incompletely understood ...
Jiawang Zhou, Jiaxin He, Yunqing Lu, Cheng Yi, Xing Chang, Lijun Tao, Ke Zhong, Haisheng Zhang, Hongxin Niu, Xiansong Wang, Zhuojia Chen, Hongsheng Wang   +11 more
doaj   +1 more source

Downregulation of the Cd38-Cyclic ADP-Ribose Signaling in Cardiomyocytes by Intermittent Hypoxia via Pten Upregulation. [PDF]

Int J Mol Sci, 2022
Takasawa S, Makino M, Uchiyama T, Yamauchi A, Sakuramoto-Tsuchida S, Itaya-Hironaka A, Takeda Y, Asai K, Shobatake R, Ota H.   +9 more
europepmc   +1 more source

Synthesis and use of cell-permeant cyclic ADP-ribose

Biochemical and Biophysical Research Communications, 2012
Cyclic ADP-ribose (cADPR) is a second messenger that acts on ryanodine receptors to mobilize Ca(2+). cADPR has a net negative charge at physiological pH making it not passively membrane permeant thereby requiring it to be injected, electroporated or loaded via liposomes.
Rosen, D, Bloor-Young, D, Squires, J, Parkesh, R, Waters, G, Vasudevan, SR, Lewis, A, Churchill, G   +7 more
openaire   +2 more sources

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, EarlyView.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source

Synthesis and biological evaluation of novel photo-clickable adenosine and cyclic ADP-ribose analogs: 8-N₃-2'-O-propargyladenosine and 8-N₃-2'-O-propargyl-cADPR. [PDF]

Bioorg Med Chem, 2022
Andy D, Gunaratne GS, Marchant JS, Walseth TF, Slama JT.   +4 more
europepmc   +1 more source

Caged cyclic ADP-ribose. Synthesis and use.

The Journal of biological chemistry, 1995
Cyclic ADP-ribose (cADPR) is a recently discovered cyclic nucleotide with Ca2+ mobilizing activity. Caged cADPR was synthesized by reacting cADPR with 2-nitrophenethyldiazoethane. Elemental analyses, 1H NMR, and extinction coefficient measurements indicate that the product contains only one caging group.
Gee, K, Aarhus, R, Hon Cheung Lee
openaire   +3 more sources