Results 201 to 210 of about 17,158 (246)

Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP

Physiological Reviews, 1997
Cells possess various mechanisms for transducing external signals to intracellular responses. The discovery of inositol 1,4,5-trisphosphate (IP3) as a messenger for mobilizing internal Ca2+ stores has centralized Ca2+ mobilization among signaling mechanisms.
Lee, HC
core   +5 more sources

Hydrolysis of NADP+by platelet CD38 in the absence of synthesis and degradation of cyclic ADP-ribose 2′-phosphate

FEBS Letters, 1999
CD38 is a multifunctional cell surface ectoenzyme that catalyzes both the synthesis of cyclic ADP-ribose from NAD+ and its hydrolysis to ADP-ribose. In this work, we investigated the metabolism of NADP+ by CD38 expressed on human platelets. Incubation of
Mauro Torti, Alessandra Bertoni, Ilaria Canobbio   +2 more
exaly   +2 more sources

Wide distribution of an enzyme that catalyzes the hydrolysis of cyclic ADP-ribose

BBA - Proteins and Proteomics, 1993
Cyclic ADP-ribose (cADPR) is a metabolite of NAD+ that is as effective as inositol trisphosphate in mobilizing intracellular Ca2+ stores. Its synthesizing enzyme, ADP-ribosyl cyclase, has been shown to be present in mammalian and invertebrate tissues. In
Cheung Lee, Robert Aarhus, R Aarhus
exaly   +2 more sources

Evidence of a role for cyclic ADP-ribose in calcium signalling and neurotransmitter release in cultured astrocytes

Journal of Neurochemistry, 2001
Astrocytes possess different, efficient ways to generate complex changes in intracellular calcium concentrations, which allow them to communicate with each other and to interact with adjacent neuronal cells.
Claudia Verderio, Santina Bruzzone, Elena Zocchi   +2 more
exaly   +2 more sources

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Medicinal Chemistry and Pharmacology of Cyclic ADP‐Ribose

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Barry V L, Potter, Timothy F, Walseth
openaire   +2 more sources

ChemInform Abstract: Preparation of Cyclic ADP‐Ribose Antagonists and Caged Cyclic ADP‐ Ribose

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
T. F. WALSETH, R. AARHUS, M. E. GURNACK, L. WONG, H.‐G. A. BREITINGER, K. R. GEE, H. C. LEE   +6 more
openaire   +1 more source

Chemistry of Cyclic ADP-Ribose and its Analogs

Current Medicinal Chemistry, 2004
Cyclic ADP-ribose (cADPR), a general mediator involved in Ca2+ signaling, has the characteristic 18-membered ring consisting of an adenine, two riboses and a pyrophosphate, in which the two primary hydroxyl groups of the riboses are linked by a pyrophosphate unit. This review focuses on the chemical synthetic studies of cADPR analogs.
Satoshi, Shuto, Akira, Matsuda
openaire   +2 more sources

Characterization of cyclic ADP-ribose and 2′-phospho-cyclic-ADP-ribose by 31P NMR spectroscopy

Bioorganic & Medicinal Chemistry Letters, 1997
Abstract The 31 P NMR spectra of the Ca 2+ mobilizing nucleotides cyclic ADP-ribose and 2′-phosphocyclic ADP-ribose have been studied. Both nucleotides show doublets of doublets in the range −9.5 to −11 ppm for the pyrophosphate group. The P-cADPR exhibits a singlet in the 0 to +4 ppm range for the 2′-phospho group.
Klaus D. Schnackerz, null Chinh Q. Vu, David Gani, Rafael Alvarez-Gonzalez, Myron K. Jacobson   +4 more
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Ca2+ release induced by cyclic ADP-ribose

Trends in Cell Biology, 1994
Cyclic ADP-ribose (cADPR) is the most potent Ca(2+)-mobilizing agent known. It has been found in many different cell types, where it is synthesized from its precursor NAD(+) by ADP-ribosyl cyclases. cADPR binds to Ca(2+) channels in the endoplasmic reticulum membrane to activate a Ca(2+)-release mechanism. This release is itself potentiated by elevated
A, Galione, A, White
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Novel analogs of cyclic-ADP-ribose: 9-Cyclic etheno-ADP-ribose and cyclic etheno-CDP-ribose

Bioorganic & Medicinal Chemistry Letters, 1996
Abstract Two novel analogs of cyclic ADP-ribose (cADPR), 9-cyclic etheno-ADP-ribose ( 1 ) and cyclic etheno-CDP-ribose ( 2 ) were synthesized. We have shown for the first time that enzymatic and biomimetic methods may proceed by different reaction pathways.
Fang-Jie Zhang, Charles J. Sih
openaire   +1 more source