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Cyclic ADP-ribose and its metabolic enzymes
Biochimie, 1995Cyclic ADP-ribose (cADPR) is a recently discovered cyclic nucleotide with Ca2+ signaling functions. There is a growing recognition that it is an endogenous modulator of the Ca(2+)-induced Ca2+ release mechanism in cells. The cyclic structure of cADPR has now been confirmed by x-ray crystallography.
Lee, HC, Graeff, R, Walseth, TF
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The crystal structure of cyclic ADP-ribose
Nature Structural Biology, 1994link_to_subscribed_fulltext
Aarhus, R, Lee, HC, Levitt, D
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Ca2+ release induced by cyclic ADP-ribose
Trends in Cell Biology, 1994Cyclic ADP-ribose (cADPR) is the most potent Ca(2+)-mobilizing agent known. It has been found in many different cell types, where it is synthesized from its precursor NAD(+) by ADP-ribosyl cyclases. cADPR binds to Ca(2+) channels in the endoplasmic reticulum membrane to activate a Ca(2+)-release mechanism. This release is itself potentiated by elevated
A, Galione, A, White
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Medicinal Chemistry and Pharmacology of Cyclic ADP‐Ribose
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Barry V L, Potter, Timothy F, Walseth
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Characterization of cyclic ADP-ribose and 2′-phospho-cyclic-ADP-ribose by 31P NMR spectroscopy
Bioorganic & Medicinal Chemistry Letters, 1997Abstract The 31 P NMR spectra of the Ca 2+ mobilizing nucleotides cyclic ADP-ribose and 2′-phosphocyclic ADP-ribose have been studied. Both nucleotides show doublets of doublets in the range −9.5 to −11 ppm for the pyrophosphate group. The P-cADPR exhibits a singlet in the 0 to +4 ppm range for the 2′-phospho group.
Klaus D. Schnackerz +4 more
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ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
F.‐J. ZHANG, C. J. SIH
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
F.‐J. ZHANG, C. J. SIH
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Preparation of cyclic ADP-ribose antagonists and caged cyclic ADP-ribose.
Methods in enzymology, 1997link_to_subscribed_fulltext
Gee, KR +6 more
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Chemistry of Cyclic ADP-Ribose and its Analogs
Current Medicinal Chemistry, 2004Cyclic ADP-ribose (cADPR), a general mediator involved in Ca2+ signaling, has the characteristic 18-membered ring consisting of an adenine, two riboses and a pyrophosphate, in which the two primary hydroxyl groups of the riboses are linked by a pyrophosphate unit. This review focuses on the chemical synthetic studies of cADPR analogs.
Satoshi, Shuto, Akira, Matsuda
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Metabotropic glutamate receptor-mediated cyclic ADP ribose signalling
Biochemical Society Transactions, 2015Group I metabotropic glutamate receptors (I-mGluRs) modulate numerous cellular functions such as specific membrane currents and neurotransmitter release linked to their ability to mobilize calcium from intracellular calcium stores. As such, most I-mGluR research to date has focused on the coupling of these receptors to phospholipase C (PLC)-dependent ...
Aidan, Kaar, Mark G, Rae
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Cyclic ADP-Ribose Measurements in Rat Pancreatic Islets
Biochemical and Biophysical Research Communications, 1997Cyclic ADP-ribose was measured by a radioimmunological procedure in rat pancreatic islets. The cyclic ADP-ribose content of the islets was much lower immediately after isolation (< or = 2.3 +/- 0.2 fmol/islet) than after a further incubation of 90 min in a salt-balanced medium (26.4 +/- 1.3 fmol/islet).
Malaisse, Willy +5 more
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