Results 231 to 240 of about 29,382 (269)

Abscisic Acid Signaling Through Cyclic ADP-Ribose in Plants

Science, 1997
Abscisic acid (ABA) is the primary hormone that mediates plant responses to stresses such as cold, drought, and salinity. Single-cell microinjection experiments in tomato were used to identify possible intermediates involved in ABA signal transduction. Cyclic ADP–ribose (cADPR) was identified as a signaling molecule in the ABA response and
Chua, NH, Foster, R, Wu, Y, Lee, HC, Graeff, R, Kuzma, J, Maréchal, E   +6 more
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Cycling Assay for Determining Intracellular Cyclic ADP-Ribose Levels

Cold Spring Harbor Protocols, 2013
Cyclic ADP-ribose (cADPR) is a Ca2+-mobilizing second messenger involved in the regulation of various physiological processes. The ability to detect changes in endogenous cADPR is a fundamental step in the identification of its role in signal transduction triggered by hormones and other stimuli.
BRUZZONE, SANTINA, Guse, Andreas H.
openaire   +3 more sources

New aspects of the physiological significance of NAD, poly ADP-ribose and cyclic ADP-ribose

Biochimie, 1995
Cyclic ADP-ribose is generated from NAD+ in glucose-stimulated beta-cells by CD38. Cyclic ADP-ribose mobilizes Ca2+ from the endoplasmic reticulum to secrete insulin. The amino acid residues of Cys-119 and Cys-201 in CD38 are essential for the synthesis and hydrolysis of cyclic ADP-ribose.
H, Okamoto, S, Takasawa, A, Tohgo
openaire   +2 more sources

Cyclic Uridine Diphosphate Glucose: A New Pyrimidine Analog of Cyclic ADP Ribose

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Cipolletta M., de Champdoré M., DE NAPOLI, LORENZO, DI FABIO, GIOVANNI, Messere A., MONTESARCHIO, DANIELA, PICCIALLI, GENNARO   +6 more
openaire   +3 more sources

Cyclic ADP-Ribose and Vasomotor Response

2002
Vascular smooth muscle (VSM) usually exists in a partially contracted state, from which it can contract further or relax in response to different physiological or pathological stimulations. This contracted state of blood vessels and their contracting and relaxing response to stimuli are often referred to as “vascular tone” and “vasomotor response ...
Pin-Lan Li, Ai-Ping Zou, William B. Campbell   +2 more
openaire   +1 more source

Cyclic ADP-Ribose: Metabolism and Calcium Mobilizing Function

1994
Publisher Summary This chapter describes the discovery of cyclic adenosine diphosphate–ribose (cADPR) as a novel endogenous Ca 2+ -mobilizing agent, and the way by which it fulfills most of the criteria necessary for it to be considered a second messenger. The enzymatic pathways for the synthesis and degradation of the metabolite are also summarized.
H C, Lee, A, Galione, T F, Walseth
openaire   +2 more sources

Cyclic ADP-Ribose and Calcium Signalling

1998
It is over 100 years since calcium was first implied as an intracellular regulator in heart by Ringer (1882). Since then its universal role as a regulator has become a cornerstone of cell physiology (Campbell 1983), and much progress has been made in our understanding of cellular calcium homeostasis and the way in which cellular stimuli are transduced ...
A. Galione, H. L. Wilson
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Cyclic ADP-ribose and ABA signal transduction

Trends in Plant Science, 1998
A new assay system utilizing ABA-inducible gene expression in tomato hypocotyl cells has placed cADPR firmly in the signal transduction cascade of this hormone[1xAbscisic acid signaling through cyclic ADP-ribose in plants. Wu, Y. et al. Science. 1997; 278: 2126–2130Crossref | PubMed | Scopus (273)See all References][1].
Gethyn J. Allen, Julian I. Schroeder
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A Redox Role for Cyclic ADP-Ribose

Science's STKE, 2001
Hypoxic pulmonary vasoconstriction is a normal physiological response that coordinates pulmonary perfusion to respiratory ventilation. NADH (reduced nicotinamide adenine dinucleotide) is thought to have a role in pulmonary artery contraction.
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Bioorganic chemistry of cyclic ADP-ribose (cADPR).

Bioorganic & medicinal chemistry, 1999
The objective of this brief review is to present an overview of the bioorganic chemistry of cyclic-ADP-ribose (cADPR) with special emphasis on the methodology used for the synthesis of analogues of cADPR. New structural analogues of cADPR can be prepared using either the biomimetic method or ADP-ribosyl cyclase from Aplysia californica.
F J, Zhang, Q M, Gu, C J, Sih
openaire   +1 more source