Results 11 to 20 of about 22,678 (88)

Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. [PDF]

PLoS ONE, 2012
Resveratrol have been known to possess many pharmacological properties including antioxidant, cardioprotective and anticancer effects. Although current studies indicate that resveratrol produces neuroprotection against neurological disorders, the precise
Lian-Mei Zhong, Yi Zong, Lin Sun, Jia-Zhi Guo, Wei Zhang, Ying He, Rui Song, Wen-Min Wang, Chun-Jie Xiao, Di Lu   +9 more
doaj   +1 more source

Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation

Frontiers in Pharmacology, 2020
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major DNA sensor responsible for cytosolic DNA-mediated innate immune response. Inhibition of cGAS may be an effective strategy for treating autoimmune diseases such as Aicardi-Goutieres syndrome and systemic ...
Junzhong Lai, Junzhong Lai, Xuan Luo, Xuan Luo, Shuoran Tian, Shuoran Tian, Xing Zhang, Xing Zhang, Shanlu Huang, Shanlu Huang, Hanze Wang, Hanze Wang, Qiumei Li, Qiumei Li, Shaoli Cai, Shaoli Cai, Qi Chen, Qi Chen   +17 more
doaj   +1 more source

Homologous and Heterologous Phosphorylations of Human Histamine H1 Receptor in Intact Cells

Journal of Pharmacological Sciences, 2004
Homologous and heterologous phosphorylations of histamine H1 receptor (H1R) in intact cells were investigated using Chinese hamster ovary cells stably co-expressing c-myctagged human histamine H1 and muscarinic M3 receptors. Increase in histamine-induced
Katsuhiro Miyoshi, Nozomi Kawakami, Shuhei Horio, Hiroyuki Fukui   +3 more
doaj   +1 more source

Cyclic nucleotide dependent dephosphorylation of regulator of G-protein signaling 18 in human platelets.

PLoS ONE, 2013
Regulator of G-protein signaling 18 (RGS18) is a GTPase-activating protein that turns off Gq signaling in platelets. RGS18 is regulated by binding to the adaptor protein 14-3-3 via phosphorylated serine residues S49 and S218 on RGS18.
Kristina Gegenbauer, Zoltan Nagy, Albert Smolenski   +2 more
doaj   +1 more source

Zonisamide Ameliorates Cognitive Impairment by Inhibiting ER Stress in a Mouse Model of Type 2 Diabetes Mellitus

Frontiers in Aging Neuroscience, 2020
Type 2 diabetes mellitus (T2DM) increases the risk of Alzheimer’s disease (AD)-like dementia and pathology. Endoplasmic reticulum stress (ERS) plays a key role in the development of cognitive impairment in T2DM. Zonisamide (ZNS) was found to suppress ERS-
Yong-Xiang He, Qi-Ying Shen, Jia-Hui Tian, Qian Wu, Qin Xue, Gui-Ping Zhang, Wei Wei, Ying-Hua Liu   +7 more
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Molecular Mechanism of Neuronal Plasticity: Induction and Maintenance of Long-Term Potentiation in the Hippocampus

Journal of Pharmacological Sciences, 2006
.: Recent studies have demonstrated that activation of enzymes can be observed in living cells in response to stimulation with neurotransmitters, hormones, growth factors, and so forth.
Eishichi Miyamoto
doaj   +1 more source

The AGC Kinase SsAgc1 Regulates Sporisorium scitamineum Mating/Filamentation and Pathogenicity

mSphere, 2019
Sporisorium scitamineum is the fungal pathogen causing severe sugarcane smut disease that leads to massive economic losses globally. S. scitamineum invades host cane by dikaryotic hyphae, formed after sexual mating of two haploid sporidia of opposite ...
Yixu Wang, Yi Zhen Deng, Guobing Cui, Chengwei Huang, Bin Zhang, Changqing Chang, Zide Jiang, Lian-Hui Zhang   +7 more
doaj   +1 more source

TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

Cell Reports, 2020
Summary: Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimmune or autoinflammatory disease.
Katherine R. Balka, Cynthia Louis, Tahnee L. Saunders, Amber M. Smith, Dale J. Calleja, Damian B. D’Silva, Fiona Moghaddas, Maximilien Tailler, Kate E. Lawlor, Yifan Zhan, Christopher J. Burns, Ian P. Wicks, Jonathan J. Miner, Benjamin T. Kile, Seth L. Masters, Dominic De Nardo   +15 more
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Identification of casein kinase 1, casein kinase 2, and cAMP-dependent protein kinase-like activities in Trypanosoma evansi

Memorias do Instituto Oswaldo Cruz, 2004
Trypanosoma evansi contains protein kinases capable of phosphorylating endogenous substrates with apparent molecular masses in the range between 20 and 205 kDa.
José Manuel Galán-Caridad, Maritza Calabokis, Graciela Uzcanga, Frank Aponte, José Bubis   +4 more
doaj   +1 more source

PPP6C Negatively Regulates STING-Dependent Innate Immune Responses

mBio, 2020
Stimulator of interferon genes (STING) is an essential adaptor protein of the innate DNA-sensing signaling pathway, which recognizes genomic DNA from invading pathogens to establish antiviral responses in host cells.
Guoxin Ni, Zhe Ma, Jason P. Wong, Zhigang Zhang, Emily Cousins, M. Ben Major, Blossom Damania   +6 more
doaj   +1 more source