ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Cyclic AMP‐dependent protein kinase of yeast [PDF]
FEBS Letters, 1981 Sy, Jose, Roselle, Michael
openaire +2 more sources
Cyclic AMP-dependent protein kinase in Molt 4b lymphoblasts: identification by photoaffinity labeling and activation in intact cells by vasoactive intestinal polypeptide (VIP) and peptide histidine isoleucine (PHI). [PDF]
, 1985 M. Sue O’Dorisio +3 more
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Hormonal Regulation of Cyclic‐AMP‐Dependent Protein Kinase of Rat Diaphragm by Epinephrine and Insulin [PDF]
, 1973 Otto Walaas, E. Walaas, Ole Grønnerød
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Cyclic AMP-Dependent Protein Kinase Isozymes of Bovine Epididymal Spermatozoa: Evidence against the Existence of an Ectokinase1 [PDF]
, 1986 Thomas D. Noland +2 more
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Release of Ca2+ by inositol 1,4,5-trisphosphate in platelet membrane vesicles is not dependent on cyclic AMP-dependent protein kinase [PDF]
, 1989 F O'Rourke +2 more
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Cyclic AMP‐dependent protein kinase stimulates the formation of polyphosphoinositides in the plasma membranes of different blood cells [PDF]
, 1983 Ágnes Enyedi +4 more
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Molecular Analysis of the Cyclic AMP-Dependent Protein Kinase A (PKA) Regulatory Subunit 1A (PRKAR1A) Gene in Patients with Carney Complex and Primary Pigmented Nodular Adrenocortical Disease (PPNAD) Reveals Novel Mutations and Clues For Pathophysiology: Augmented PKA Signaling is Associated with Adrenal Tumorigenesis in PPNAD [PDF]
, 2002 Lionel Groussin +12 more
openalex +1 more source