Results 11 to 20 of about 64,381 (295)

Kv4.2 Phosphorylation by Cyclic AMP-dependent Protein Kinase [PDF]

Journal of Biological Chemistry, 2000
Recent evidence suggests that K(+) channels composed of Kv4.2 alpha-subunits underlie a transient current in hippocampal CA1 neurons and ventricular myocytes, and activation of the cAMP second messenger cascade has been shown to modulate this transient current. We determined if Kv4.2 alpha-subunits were directly phosphorylated by cAMP-dependent protein
A E, Anderson, J P, Adams, Y, Qian, R G, Cook, P J, Pfaffinger, J D, Sweatt   +5 more
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Cyclic AMP‐dependent protein kinase does not phosphorylate cyclic GMP‐dependent protein kinase in vitro [PDF]

FEBS Letters, 1983
The autophosphorylation reaction of purified cGMP‐dependent protein kinase has been studied. Apparent initial rates of autophosphorylation in the absence of cyclic nucleotides and in the presence of cGMP and cAMP are 0.006, 0.04, 0.4 mol. Pi incorp./min−1.mol cGMP‐kinase subunit−1.
Hofmann, F., Gensheimer, H.-P.
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Yeast cyclic AMP‐dependent protein kinase [PDF]

FEBS Letters, 1983
We have purified cyclic AMP‐dependent protein kinase from the yeast Saccharomyces cerevisiae. The purified enzyme was inactive in the absence of cyclic AMP and displayed two protein bands on SDS gel electrophoresis. One was identified as the cAMP‐binding protein by chromatography on cAMP‐agarose. M r of the latter was 50 000 while the catalytic subunit
openaire   +2 more sources

Association of cyclic-AMP-dependent protein kinase with neurofilaments [PDF]

Biochemical Journal, 1992
Neurofilament preparations isolated from bovine spinal cord contain cyclic-AMP-dependent protein kinase (PKA) activity. Treatment of this preparation with cyclic AMP, to dissociate the regulatory subunit of the kinase from the catalytic subunit, resulted in retention of the kinase activity but loss of cyclic AMP regulation.
A, Dosemeci, H C, Pant
openaire   +2 more sources

Brain region-specific decrease in the activity and expression of protein kinase A in the frontal cortex of regressive autism. [PDF]

PLoS ONE, 2011
Autism is a severe neurodevelopmental disorder that is characterized by impaired language, communication, and social skills. In regressive autism, affected children first show signs of normal social and language development but eventually lose these ...
Lina Ji, Ved Chauhan, Michael J Flory, Abha Chauhan   +3 more
doaj   +1 more source

Protein phosphorylation in yeast mitochondria [PDF]

, 1987
We describe the identification and submitochondrial localization of four protein kinases and of their target proteins in derepressed yeast mitochondria. The activity of one of the kinases depends on the presence of cyclic AMP (cAMP).
Ashwell, Bandlow, Bandlow, Barrera, Bradford, Chandrasekaran, Chock, Daum, De Vendittis, Dimino, Douglas, Eraso, Fang, Heil, Henriksson, Hixson, Kim, Kitagawa, Krebs, Lastick, Linn, Mahler, Mahler, Matsumoto, Matsumoto, Matsumoto, Pall, Racker, Rigobello, Rittenhouse, Rödel, Steinberg, Steinberg, Suissa, Towbin, Van der Plaat, Vardanis, Wang   +37 more
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Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. [PDF]

PLoS ONE, 2012
Resveratrol have been known to possess many pharmacological properties including antioxidant, cardioprotective and anticancer effects. Although current studies indicate that resveratrol produces neuroprotection against neurological disorders, the precise
Lian-Mei Zhong, Yi Zong, Lin Sun, Jia-Zhi Guo, Wei Zhang, Ying He, Rui Song, Wen-Min Wang, Chun-Jie Xiao, Di Lu   +9 more
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Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation

Frontiers in Pharmacology, 2020
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major DNA sensor responsible for cytosolic DNA-mediated innate immune response. Inhibition of cGAS may be an effective strategy for treating autoimmune diseases such as Aicardi-Goutieres syndrome and systemic ...
Junzhong Lai, Junzhong Lai, Xuan Luo, Xuan Luo, Shuoran Tian, Shuoran Tian, Xing Zhang, Xing Zhang, Shanlu Huang, Shanlu Huang, Hanze Wang, Hanze Wang, Qiumei Li, Qiumei Li, Shaoli Cai, Shaoli Cai, Qi Chen, Qi Chen   +17 more
doaj   +1 more source

Role of cyclic AMP in the control of cell-specific gene expression [PDF]

, 1993
Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael, Nitsch, Doris, Schmid, Wolfgang, Schütz, Günther   +3 more
core   +1 more source

Cyclic nucleotide dependent dephosphorylation of regulator of G-protein signaling 18 in human platelets.

PLoS ONE, 2013
Regulator of G-protein signaling 18 (RGS18) is a GTPase-activating protein that turns off Gq signaling in platelets. RGS18 is regulated by binding to the adaptor protein 14-3-3 via phosphorylated serine residues S49 and S218 on RGS18.
Kristina Gegenbauer, Zoltan Nagy, Albert Smolenski   +2 more
doaj   +1 more source