Results 11 to 20 of about 87,184 (381)

Association of cyclic-AMP-dependent protein kinase with neurofilaments [PDF]

Biochemical Journal, 1992
Neurofilament preparations isolated from bovine spinal cord contain cyclic-AMP-dependent protein kinase (PKA) activity. Treatment of this preparation with cyclic AMP, to dissociate the regulatory subunit of the kinase from the catalytic subunit, resulted in retention of the kinase activity but loss of cyclic AMP regulation.
H C Pant, Ayse Dosemeci
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Kv4.2 Phosphorylation by Cyclic AMP-dependent Protein Kinase [PDF]

Journal of Biological Chemistry, 2000
Recent evidence suggests that K(+) channels composed of Kv4.2 alpha-subunits underlie a transient current in hippocampal CA1 neurons and ventricular myocytes, and activation of the cAMP second messenger cascade has been shown to modulate this transient current. We determined if Kv4.2 alpha-subunits were directly phosphorylated by cAMP-dependent protein
J. David Sweatt, J. Paige Adams, Richard G. Cook, Yan Qian, Anne E. Anderson, Paul J. Pfaffinger   +5 more
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Regulation of transcription by cyclic AMP-dependent protein kinase. [PDF]

Proceedings of the National Academy of Sciences, 1989
cAMP-dependent protein kinase (PKA; ATP: protein phosphotransferase; EC 2.7.1.37) appears to be the major mediator of cAMP responses in mammalian cells. We have investigated the role of PKA subunits in the regulation of specific genes in response to cAMP by cotransfection of wild-type or mutant subunits of PKA together with cAMP-inducible reporter ...
Pamela L. Mellon, G S McKnight, C H Clegg, L A Correll   +3 more
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Substrate specificity of the cyclic AMP-dependent protein kinase. [PDF]

Proceedings of the National Academy of Sciences, 1975
The protein substrate specificity of the catalytic subunit of rabbit skeletal muscle cyclic AMP-dependent protein kinase (EC 2.7.1.37; ATP:protein phosphotransferase) has been studied using genetic variants of beta casein. It was found that beta casein-B was phosphorylated at a much greater rate than beta caseins A1, A2, A3, or C.
David B. Bylund, Tung-Shiuh Huang, Bruce E. Kemp, Edwin G. Krebs   +3 more
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Yeast cyclic AMP‐dependent protein kinase [PDF]

FEBS Letters, 1983
We have purified cyclic AMP‐dependent protein kinase from the yeast Saccharomyces cerevisiae. The purified enzyme was inactive in the absence of cyclic AMP and displayed two protein bands on SDS gel electrophoresis. One was identified as the cAMP‐binding protein by chromatography on cAMP‐agarose. M r of the latter was 50 000 while the catalytic subunit
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Ezrin is a cyclic AMP-dependent protein kinase anchoring protein [PDF]

The EMBO Journal, 1997
cAMP-dependent protein kinase (A-kinase) anchoring proteins (AKAPs) are responsible for the subcellular sequestration of the type II A-kinase. Previously, we identified a 78 kDa AKAP which was enriched in gastric parietal cells. We have now purified the 78 kDa AKAP to homogeneity from gastric fundic mucosal supernates using type II A-kinase regulatory ...
Alvin J. Bradford, Paul Mangeat, Daniel T. Dransfield, Jenetta Smith, Marianne Martin, Christian Roy, James R. Goldenring   +6 more
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Cyclic AMP‐dependent protein kinase does not phosphorylate cyclic GMP‐dependent protein kinase in vitro [PDF]

FEBS Letters, 1983
The autophosphorylation reaction of purified cGMP‐dependent protein kinase has been studied. Apparent initial rates of autophosphorylation in the absence of cyclic nucleotides and in the presence of cGMP and cAMP are 0.006, 0.04, 0.4 mol. Pi incorp./min−1.mol cGMP‐kinase subunit−1.
Franz Hofmann, Hans-Peter Gensheimer
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Protein phosphorylation in yeast mitochondria [PDF]

, 1987
We describe the identification and submitochondrial localization of four protein kinases and of their target proteins in derepressed yeast mitochondria. The activity of one of the kinases depends on the presence of cyclic AMP (cAMP).
Ashwell, Bandlow, Bandlow, Barrera, Bradford, Chandrasekaran, Chock, Daum, De Vendittis, Dimino, Douglas, Eraso, Fang, Heil, Henriksson, Hixson, Kim, Kitagawa, Krebs, Lastick, Linn, Mahler, Mahler, Matsumoto, Matsumoto, Matsumoto, Pall, Racker, Rigobello, Rittenhouse, Rödel, Steinberg, Steinberg, Suissa, Towbin, Van der Plaat, Vardanis, Wang   +37 more
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Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. [PDF]

PLoS ONE, 2012
Resveratrol have been known to possess many pharmacological properties including antioxidant, cardioprotective and anticancer effects. Although current studies indicate that resveratrol produces neuroprotection against neurological disorders, the precise
Lian-Mei Zhong, Yi Zong, Lin Sun, Jia-Zhi Guo, Wei Zhang, Ying He, Rui Song, Wen-Min Wang, Chun-Jie Xiao, Di Lu   +9 more
doaj   +1 more source

Role of cyclic AMP in the control of cell-specific gene expression [PDF]

, 1993
Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael, Nitsch, Doris, Schmid, Wolfgang, Schütz, Günther   +3 more
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