Results 31 to 40 of about 64,058 (295)

Engineering a bioluminescent indicator for cyclic AMP-dependent protein kinase [PDF]

Biochemical Journal, 1991
cDNA coding for the luciferase in the firefly Photinus pyralis was amplified in vitro to generate cyclic AMP-dependent protein kinase phosphorylation sites. The DNA was transcribed and translated to generate light-emitting protein. A valine at position 217 was mutated to arginine to generate a site RRFS and the heptapeptide kemptide, the ...
G B, Sala-Newby, A K, Campbell
openaire   +2 more sources

Identification of casein kinase 1, casein kinase 2, and cAMP-dependent protein kinase-like activities in Trypanosoma evansi

Memorias do Instituto Oswaldo Cruz, 2004
Trypanosoma evansi contains protein kinases capable of phosphorylating endogenous substrates with apparent molecular masses in the range between 20 and 205 kDa.
José Manuel Galán-Caridad, Maritza Calabokis, Graciela Uzcanga, Frank Aponte, José Bubis   +4 more
doaj   +1 more source

TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

Cell Reports, 2020
Summary: Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimmune or autoinflammatory disease.
Katherine R. Balka, Cynthia Louis, Tahnee L. Saunders, Amber M. Smith, Dale J. Calleja, Damian B. D’Silva, Fiona Moghaddas, Maximilien Tailler, Kate E. Lawlor, Yifan Zhan, Christopher J. Burns, Ian P. Wicks, Jonathan J. Miner, Benjamin T. Kile, Seth L. Masters, Dominic De Nardo   +15 more
doaj   +1 more source

Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. [PDF]

, 2018
Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains ...
Liu, Fu-Tong, Wan, Lei, Yang, Ri-Yao
core   +2 more sources

Phosphorylation of β-Catenin by Cyclic AMP-dependent Protein Kinase [PDF]

Journal of Biological Chemistry, 2006
Beta-catenin is a signaling molecule that promotes cell proliferation by the induction of gene transcription through the activation of T-cell factor (TCF)/lymphoid enhancer factor (LEF) transcription factors. The canonical mechanism of the regulation of beta-catenin involves its phosphorylation by casein kinase 1 at the Ser-45 site and by glycogen ...
Sebastien, Taurin, Nathan, Sandbo, Yimin, Qin, Darren, Browning, Nickolai O, Dulin   +4 more
openaire   +2 more sources

β2-Adrenergic Receptor-Mediated Histamine H1 Receptor Down-Regulation: Another Possible Advantage of β2 Agonists in Asthmatic Therapy

Journal of Pharmacological Sciences, 2004
To clarify heterologous regulation of a receptor is important in considering medication. Histamine constricts the airway smooth muscle through the action to the H1 receptor (H1R), which contributes to asthma.
Nozomi Kawakami, Katsuhiro Miyoshi, Shuhei Horio, Hiroyuki Fukui   +3 more
doaj   +1 more source

How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]

, 2017
Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias, Mukherjee, Shaeri, Schlaermann, Philipp   +2 more
core   +2 more sources

MAPK Regulation of Sclerotial Development in Sclerotinia sclerotiorum Is Linked with pH and cAMP Sensing

Molecular Plant-Microbe Interactions, 2004
Sclerotial development is fundamental to the disease cycle of the omnivorous broad host range fungal phytopathogen Sclerotinia sclerotiorum. We have isolated a highly conserved homolog of ERK-type mitogen-activated protein kinases (MAPKs) from S ...
Changbin Chen, Arye Harel, Rena Gorovoits, Oded Yarden, Martin B. Dickman   +4 more
doaj   +1 more source

PPP6C Negatively Regulates STING-Dependent Innate Immune Responses

mBio, 2020
Stimulator of interferon genes (STING) is an essential adaptor protein of the innate DNA-sensing signaling pathway, which recognizes genomic DNA from invading pathogens to establish antiviral responses in host cells.
Guoxin Ni, Zhe Ma, Jason P. Wong, Zhigang Zhang, Emily Cousins, M. Ben Major, Blossom Damania   +6 more
doaj   +1 more source

Cyclic AMP signalling in pancreatic islets [PDF]

, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Furman, Brian, Ong, Wee Kiat, Pyne, Nigel J.   +2 more
core   +1 more source