Results 11 to 20 of about 34,004 (246)

Downstream Targets of Cyclic Nucleotides in Plants

Frontiers in Plant Science, 2018
Efficient integration of various external and internal signals is required to maintain adaptive cellular function. Numerous distinct signal transduction systems have evolved to allow cells to receive these inputs, to translate their codes and ...
Brygida Świeżawska, Maria Duszyn, Krzysztof Jaworski, Adriana Szmidt-Jaworska   +3 more
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Characterization of Proteins Regulated by Androgen and Protein Kinase a Signaling in VCaP Prostate Cancer Cells

Biomedicines, 2021
Androgen signaling via the androgen receptor (AR) is involved in normal prostate development and prostate cancer progression. In addition to androgen binding, a variety of protein kinases, including cyclic AMP-dependent protein kinase A (PKA), can ...
Hye-Jin You, Byong-Chul You, Jong-Kwang Kim, Jae-Min Park, Bo-Seul Song, Jae-Kyung Myung   +5 more
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Role of Pentacyclic Triterpenoids in Chemoprevention and Anticancer Treatment: An Overview on Targets and Underling Mechanisms

Journal of Pharmacopuncture, 2019
DNA: Deoxyribonucleic acid, BRCA1: Breast cancer gene 1, BRCA2: Breast cancer gene 2,WHO: World Health Organization, Nrf2: Nuclear factor erythroid 2 [NF-E2]-related factor 2 , NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells, MDR ...
Mahavir H. Ghante, Prasad G. Jamkhande
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Brain region-specific decrease in the activity and expression of protein kinase A in the frontal cortex of regressive autism. [PDF]

PLoS ONE, 2011
Autism is a severe neurodevelopmental disorder that is characterized by impaired language, communication, and social skills. In regressive autism, affected children first show signs of normal social and language development but eventually lose these ...
Lina Ji, Ved Chauhan, Michael J Flory, Abha Chauhan   +3 more
doaj   +1 more source

Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. [PDF]

PLoS ONE, 2012
Resveratrol have been known to possess many pharmacological properties including antioxidant, cardioprotective and anticancer effects. Although current studies indicate that resveratrol produces neuroprotection against neurological disorders, the precise
Lian-Mei Zhong, Yi Zong, Lin Sun, Jia-Zhi Guo, Wei Zhang, Ying He, Rui Song, Wen-Min Wang, Chun-Jie Xiao, Di Lu   +9 more
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Cyclic AMP‐dependent protein kinase does not phosphorylate cyclic GMP‐dependent protein kinase in vitro [PDF]

FEBS Letters, 1983
The autophosphorylation reaction of purified cGMP‐dependent protein kinase has been studied. Apparent initial rates of autophosphorylation in the absence of cyclic nucleotides and in the presence of cGMP and cAMP are 0.006, 0.04, 0.4 mol. Pi incorp./min−1.mol cGMP‐kinase subunit−1.
Hofmann, F., Gensheimer, H.-P.
openaire   +2 more sources

Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation

Frontiers in Pharmacology, 2020
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major DNA sensor responsible for cytosolic DNA-mediated innate immune response. Inhibition of cGAS may be an effective strategy for treating autoimmune diseases such as Aicardi-Goutieres syndrome and systemic ...
Junzhong Lai, Junzhong Lai, Xuan Luo, Xuan Luo, Shuoran Tian, Shuoran Tian, Xing Zhang, Xing Zhang, Shanlu Huang, Shanlu Huang, Hanze Wang, Hanze Wang, Qiumei Li, Qiumei Li, Shaoli Cai, Shaoli Cai, Qi Chen, Qi Chen   +17 more
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Homologous and Heterologous Phosphorylations of Human Histamine H1 Receptor in Intact Cells

Journal of Pharmacological Sciences, 2004
Homologous and heterologous phosphorylations of histamine H1 receptor (H1R) in intact cells were investigated using Chinese hamster ovary cells stably co-expressing c-myctagged human histamine H1 and muscarinic M3 receptors. Increase in histamine-induced
Katsuhiro Miyoshi, Nozomi Kawakami, Shuhei Horio, Hiroyuki Fukui   +3 more
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Cyclic nucleotide dependent dephosphorylation of regulator of G-protein signaling 18 in human platelets.

PLoS ONE, 2013
Regulator of G-protein signaling 18 (RGS18) is a GTPase-activating protein that turns off Gq signaling in platelets. RGS18 is regulated by binding to the adaptor protein 14-3-3 via phosphorylated serine residues S49 and S218 on RGS18.
Kristina Gegenbauer, Zoltan Nagy, Albert Smolenski   +2 more
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Engineering a bioluminescent indicator for cyclic AMP-dependent protein kinase [PDF]

Biochemical Journal, 1991
cDNA coding for the luciferase in the firefly Photinus pyralis was amplified in vitro to generate cyclic AMP-dependent protein kinase phosphorylation sites. The DNA was transcribed and translated to generate light-emitting protein. A valine at position 217 was mutated to arginine to generate a site RRFS and the heptapeptide kemptide, the ...
G B, Sala-Newby, A K, Campbell
openaire   +2 more sources