Results 11 to 20 of about 64,058 (295)

Downstream Targets of Cyclic Nucleotides in Plants

Frontiers in Plant Science, 2018
Efficient integration of various external and internal signals is required to maintain adaptive cellular function. Numerous distinct signal transduction systems have evolved to allow cells to receive these inputs, to translate their codes and ...
Brygida Świeżawska, Maria Duszyn, Krzysztof Jaworski, Adriana Szmidt-Jaworska   +3 more
doaj   +1 more source

Characterization of Proteins Regulated by Androgen and Protein Kinase a Signaling in VCaP Prostate Cancer Cells

Biomedicines, 2021
Androgen signaling via the androgen receptor (AR) is involved in normal prostate development and prostate cancer progression. In addition to androgen binding, a variety of protein kinases, including cyclic AMP-dependent protein kinase A (PKA), can ...
Hye-Jin You, Byong-Chul You, Jong-Kwang Kim, Jae-Min Park, Bo-Seul Song, Jae-Kyung Myung   +5 more
doaj   +1 more source

Role of Pentacyclic Triterpenoids in Chemoprevention and Anticancer Treatment: An Overview on Targets and Underling Mechanisms

Journal of Pharmacopuncture, 2019
DNA: Deoxyribonucleic acid, BRCA1: Breast cancer gene 1, BRCA2: Breast cancer gene 2,WHO: World Health Organization, Nrf2: Nuclear factor erythroid 2 [NF-E2]-related factor 2 , NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells, MDR ...
Mahavir H. Ghante, Prasad G. Jamkhande
doaj   +1 more source

Brain region-specific decrease in the activity and expression of protein kinase A in the frontal cortex of regressive autism. [PDF]

PLoS ONE, 2011
Autism is a severe neurodevelopmental disorder that is characterized by impaired language, communication, and social skills. In regressive autism, affected children first show signs of normal social and language development but eventually lose these ...
Lina Ji, Ved Chauhan, Michael J Flory, Abha Chauhan   +3 more
doaj   +1 more source

Protein phosphorylation in yeast mitochondria [PDF]

, 1987
We describe the identification and submitochondrial localization of four protein kinases and of their target proteins in derepressed yeast mitochondria. The activity of one of the kinases depends on the presence of cyclic AMP (cAMP).
Ashwell, Bandlow, Bandlow, Barrera, Bradford, Chandrasekaran, Chock, Daum, De Vendittis, Dimino, Douglas, Eraso, Fang, Heil, Henriksson, Hixson, Kim, Kitagawa, Krebs, Lastick, Linn, Mahler, Mahler, Matsumoto, Matsumoto, Matsumoto, Pall, Racker, Rigobello, Rittenhouse, Rödel, Steinberg, Steinberg, Suissa, Towbin, Van der Plaat, Vardanis, Wang   +37 more
core   +2 more sources

Cyclic AMP‐dependent protein kinase does not phosphorylate cyclic GMP‐dependent protein kinase in vitro [PDF]

FEBS Letters, 1983
The autophosphorylation reaction of purified cGMP‐dependent protein kinase has been studied. Apparent initial rates of autophosphorylation in the absence of cyclic nucleotides and in the presence of cGMP and cAMP are 0.006, 0.04, 0.4 mol. Pi incorp./min−1.mol cGMP‐kinase subunit−1.
Hofmann, F., Gensheimer, H.-P.
openaire   +2 more sources

Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. [PDF]

PLoS ONE, 2012
Resveratrol have been known to possess many pharmacological properties including antioxidant, cardioprotective and anticancer effects. Although current studies indicate that resveratrol produces neuroprotection against neurological disorders, the precise
Lian-Mei Zhong, Yi Zong, Lin Sun, Jia-Zhi Guo, Wei Zhang, Ying He, Rui Song, Wen-Min Wang, Chun-Jie Xiao, Di Lu   +9 more
doaj   +1 more source

3',5'-Cyclic Adenosine Monophosphate- and Ca2+-Calmodulin-Dependent Endogenous Protein Phosphorylation Activity in Membranes of the Bovine Chromaffin Secretory Vesicles: Identification of Two Phosphorylated Components as Tyrosine Hydroxylase and Protein Kinase Regulatory Subunit Type II [PDF]

, 1983
: Membranes of the secretory vesicles from bovine adrenal medulla were investigated for the presence of the endogenous protein phosphorylation activity. Seven phosphoprotein bands in the molecular weight range of 250,000 to 30,000 were observed by means ...
Amy C. M., Dahl G., Douglas W. W., Flodgaard H., Gratzl M., Gratzl M., Kilpatrick D. L., Krueger B. K., Kuo I. C. Y., Levitt M., Llinas R. R., Lohmann S. M., Manfred Gratzl, Marek Treiman, Max S. R., Nimmo H. G., Petrack B., Rangel-Aldao R., Rosen O. M., Sharma R. K., Sillen L. G., Treiman M., Walter U., Walter U., Waymire J. C., Wolfgang Weber, Yamauchi T., Yamauchi T.   +27 more
core   +1 more source

Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation

Frontiers in Pharmacology, 2020
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major DNA sensor responsible for cytosolic DNA-mediated innate immune response. Inhibition of cGAS may be an effective strategy for treating autoimmune diseases such as Aicardi-Goutieres syndrome and systemic ...
Junzhong Lai, Junzhong Lai, Xuan Luo, Xuan Luo, Shuoran Tian, Shuoran Tian, Xing Zhang, Xing Zhang, Shanlu Huang, Shanlu Huang, Hanze Wang, Hanze Wang, Qiumei Li, Qiumei Li, Shaoli Cai, Shaoli Cai, Qi Chen, Qi Chen   +17 more
doaj   +1 more source

Role of cyclic AMP in the control of cell-specific gene expression [PDF]

, 1993
Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael, Nitsch, Doris, Schmid, Wolfgang, Schütz, Günther   +3 more
core   +1 more source