Results 211 to 220 of about 87,184 (381)

Expanding the Reach of Membrane Protein–Ligand Interaction Studies Through the Integration of Mass Spectrometry and Membrane Mimetics

PROTEOMICS, EarlyView.
ABSTRACT Mass spectrometry (MS) offers robust, label‐free approaches for characterizing ligand–protein interactions through two main strategies: affinity‐based and stability‐based assays. However, their application to membrane proteins (MPs)—a major class of drug targets—has been limited by challenges such as structural complexity, low native ...
Jonathon C. Lambos, Ashim Bhattacharya, Mohammed Al‐Seragi, Franck Duong van Hoa   +3 more
wiley   +1 more source

AARS1 and AARS2: From Protein Synthesis to Lactylation-Driven Oncogenesis. [PDF]

Biomolecules
Gao L, Guo J, Jia R.
europepmc   +1 more source

A cytosolic cyclic AMP-dependent protein kinase in Dictyostelium discoideum. II. Developmental regulation.

, 1984
Ben H. Leichtling, Irene Majerfeld, Eva Spitz, K Schaller, Clive Woffendin, Shizuko Kakinuma, H.V. Rickenberg   +6 more
openalex   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

"Cyclic nucleotides in plants: from obscure messengers to central regulators". [PDF]

Front Plant Sci
Świeżawska-Boniecka B, Szmidt-Jaworska A.   +1 more
europepmc   +1 more source

Liver isozyme of rabbit glycogen synthase. Amino acid sequences surrounding phosphorylation sites recognized by cyclic AMP-dependent protein kinase.

, 1986
Y H Wang, A.W. Bell, Mark A. Hermodson, Peter J. Roach   +3 more
openalex   +1 more source

Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells.

Biochemical Journal, 1991
Mårten, Sandberg, tj, E. Butt, C. Nolte, Lilo Fischer, Maria Halbrugge, Jerlyn, Beltman, Tore, Jahnsen, tt, H. Genieser, B. Jastorff, U. Walter   +14 more
semanticscholar   +1 more source

EXERCISE EFFECTS ON MUSCLE GLUCOSE UPTAKE AND INSULIN ACTION [PDF]

, 2008
Derave, Wim
core   +1 more source

Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration

Small Science, EarlyView.
Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello, KeeSiang Lim, Giacomo Nisini, Vadim S. Pokrovsky, João Conde, Francesco Simone Ruggeri   +5 more
wiley   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa. [PDF]

FEBS Lett
Vainionpää K, Montaser AB, Leinonen H.
europepmc   +1 more source