Results 201 to 210 of about 32,015 (246)

Phosphorylation of Tau by Cyclic-AMP-Dependent Protein Kinase

Dementia and Geriatric Cognitive Disorders, 1993
Alzheimer's disease paired helical filaments contain abnormally phosphorylated tau (PHF-tau) which has reduced electrophoretic mobility on sodium dodecyl sulphate polyacrylamide electrophoresis. We have investigated the effects of cyclic-AMP-dependent protein kinase (PKA) on recombinant human tau isoforms and two recombinant tau fragments.
J, Robertson, T L, Loviny, M, Goedert, R, Jakes, K J, Murray, B H, Anderton, D P, Hanger   +6 more
openaire   +2 more sources

Phosphorylation of casein by cyclic AMP-dependent protein kinase

Biochemical and Biophysical Research Communications, 1977
Abstract The catalytic subunit of rabbit muscle cyclic AMP-dependent protein kinase (EC 2.7.1.37; ATP:protein transferase) has been tested on a variety of caseins. The B variant of β-casein was phosphorylated at a much greater rate than other β-caseins, αs1-caseins, and κ-caseins. Whole casein homozygous for β-casein B was phosphorylated at 2.5 times
E W, Bingham, M L, Groves, E S, Szymanski   +2 more
openaire   +2 more sources

Inhibition of cyclic AMP-dependent protein kinase by curcumin

Phytochemistry, 1996
Curcumin [diferuloylmethane; 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione], a major bioactive secondary metabolite found in the rhizomes of turmeric (Curcuma longa), is an inhibitor of Ca(2+)- and phospholipid-dependent protein kinase C (PKC) and of the catalytic subunit (cAK) of cyclic AMP-dependent protein kinase (IC50 values 15 and 4 ...
M, Hasmeda, G M, Polya
openaire   +2 more sources

Synthetic substrate for cyclic AMP-dependent protein kinase

Nature, 1975
MOST hormones and neurotransmitters are thought to stimulate the synthesis of adenosine 3′,5′-cyclic monophosphate (cyclic AMP) which in turn activates protein kinases1. On activation, the protein kinases transfer the terminal phosphate group of ATP to serine or threonine residues in enzymic or membrane proteins involved in metabolic regulation ...
P, Daile, P R, Carnegie, J D, Young
openaire   +2 more sources

Cyclic AMP-dependent and -independent protein kinases in HeLa cells

Archives of Biochemistry and Biophysics, 1980
Abstract The protein kinase activities of HeLa cell cytosol have been characterized. Differentiation between cyclic AMP-dependent and -independent kinase activities was achieved by the use of purified specific cyclic AMP-dependent protein kinase inhibitor.
J P, Gray, R A, Johnson, D L, Friedman
openaire   +2 more sources

Cyclic AMP-dependent protein kinase phosphorylates serine378 in vitronectin

Biochemical and Biophysical Research Communications, 1991
We previously observed that Ser378 in the heparin-binding domain of vitronectin becomes phosphorylated by a protein kinase in plasma upon addition of ATP and divalent cations. We now report that purified plasma vitronectin contains approximately 2.5 mol of phosphate per mol of protein and that vitronectin becomes phosphorylated during biosynthesis in ...
J H, Mehringer, C J, Weigel, D M, Tollefsen   +2 more
openaire   +2 more sources

Inhibition of cyclic AMP dependent protein kinase by vanadyl sulfate

JBIC Journal of Biological Inorganic Chemistry, 2006
Vanadium salts influence the activities of a number of mammalian enzymes in vitro but the mechanisms by which low concentrations of vanadium ameliorate the effects of diabetes in vivo remain poorly understood. The hypothesis that vanadium compounds act by inhibiting protein tyrosine phosphatases has attracted most support.
Kioumars A, Jelveh, Rachel, Zhande, Roger W, Brownsey   +2 more
openaire   +2 more sources

Cisplatin resistance in cyclic AMP-dependent protein kinase mutants

Pharmacology & Therapeutics, 1998
The emergence of cisplatin resistance poses a major problem to the successful treatment of a variety of human malignancies. Therefore, understanding the molecular mechanisms that underlie cisplatin resistance could significantly improve the clinical efficacy of this cytotoxic agent.
M E, Cvijic, W L, Yang, K V, Chin
openaire   +2 more sources

Distribution of cyclic AMP-dependent protein kinase in the bovine cornea

Experimental Eye Research, 1981
Soluble and particulate fractions of bovine corneal epithelium, stroma and endothelium were prepared and assayed for protein kinase activity. All preparations exhibited measurable activity in the absence of cyclic AMP (cyclic AMP-independent activity) as well as significant enzyme stimulation in its presence (cyclic AMP-dependent activity).
R J, Walkenbach, R D, LeGrand, R E, Barr
openaire   +2 more sources

Effect of cyclic AMP-dependent protein kinases on gene expression

Advances in Enzyme Regulation, 1982
Mechanisms for regulating activation of cyclic AMP-dependent protein kinase were investigated and a possible biological role of this enzyme was elucidated. Autophosphorylation of cyclic AMP-dependent protein kinase was shown to occur via an intramolecular mechanism: the regulatory subunit undergoes phosphorylation only within the holoenzyme.
E S, Severin, M V, Nesterova
openaire   +2 more sources