Results 201 to 210 of about 34,004 (246)
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Effect of indomethacin on the cyclic AMP-dependent protein kinase
European Journal of Pharmacology, 1980Indomethacin inhibited cyclic AMP-dependent protein kinase activity in small intestine in in vivo experiments. An inverse pattern of variation was exhibited by acetyl salicylic acid, eterylate and benorylate, acetyl-p-amino-phenol being inactive. Indomethacin, acetyl salicylic acid, eterylate and benorylate increased the protein kinase activity in ...
R E, Catalán +4 more
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Phosphorylation of casein by cyclic AMP-dependent protein kinase
Biochemical and Biophysical Research Communications, 1977Abstract The catalytic subunit of rabbit muscle cyclic AMP-dependent protein kinase (EC 2.7.1.37; ATP:protein transferase) has been tested on a variety of caseins. The B variant of β-casein was phosphorylated at a much greater rate than other β-caseins, αs1-caseins, and κ-caseins. Whole casein homozygous for β-casein B was phosphorylated at 2.5 times
E W, Bingham +2 more
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Cisplatin resistance in cyclic AMP-dependent protein kinase mutants
Pharmacology & Therapeutics, 1998The emergence of cisplatin resistance poses a major problem to the successful treatment of a variety of human malignancies. Therefore, understanding the molecular mechanisms that underlie cisplatin resistance could significantly improve the clinical efficacy of this cytotoxic agent.
M E, Cvijic, W L, Yang, K V, Chin
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Inhibition of cyclic AMP dependent protein kinase by vanadyl sulfate
JBIC Journal of Biological Inorganic Chemistry, 2006Vanadium salts influence the activities of a number of mammalian enzymes in vitro but the mechanisms by which low concentrations of vanadium ameliorate the effects of diabetes in vivo remain poorly understood. The hypothesis that vanadium compounds act by inhibiting protein tyrosine phosphatases has attracted most support.
Kioumars A, Jelveh +2 more
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Cyclic AMP-dependent protein kinase from Ustilago maydis
Molecular and Cellular Biochemistry, 1984Ustilago maydis was surveyed for cyclic AMP-dependent protein kinase activity. Using a combination of ion-exchange and molecular filtration techniques, we demonstrate that there is only one form of cyclic AMP-dependent protein kinase in the cytosolic fraction of the fungus.
N, Kerner, S, Passeron
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Reversible inhibition of cyclic AMP-dependent protein kinase by insulin
Molecular and Cellular Biochemistry, 1978Extracts of fasted rat diaphragms, previously treated with or without insulin were assayed for glycogen synthase, protein kinase and cyclic [3H]-AMP binding. Treatment with insulin produced an elevation in the % of glycogen synthase I and a concurrent decrease in cyclic AMP-dependent protein kinase activity and cyclic [3H]-AMP binding.
R J, Walkenbach, R, Hazen, J, Larner
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Effect of cyclic AMP-dependent protein kinases on gene expression
Advances in Enzyme Regulation, 1982Mechanisms for regulating activation of cyclic AMP-dependent protein kinase were investigated and a possible biological role of this enzyme was elucidated. Autophosphorylation of cyclic AMP-dependent protein kinase was shown to occur via an intramolecular mechanism: the regulatory subunit undergoes phosphorylation only within the holoenzyme.
E S, Severin, M V, Nesterova
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Distribution of cyclic AMP-dependent protein kinase in the bovine cornea
Experimental Eye Research, 1981Soluble and particulate fractions of bovine corneal epithelium, stroma and endothelium were prepared and assayed for protein kinase activity. All preparations exhibited measurable activity in the absence of cyclic AMP (cyclic AMP-independent activity) as well as significant enzyme stimulation in its presence (cyclic AMP-dependent activity).
R J, Walkenbach, R D, LeGrand, R E, Barr
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Cyclic AMP-dependent and -independent protein kinases in HeLa cells
Archives of Biochemistry and Biophysics, 1980Abstract The protein kinase activities of HeLa cell cytosol have been characterized. Differentiation between cyclic AMP-dependent and -independent kinase activities was achieved by the use of purified specific cyclic AMP-dependent protein kinase inhibitor.
J P, Gray, R A, Johnson, D L, Friedman
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Cyclic AMP-dependent protein kinase phosphorylates serine378 in vitronectin
Biochemical and Biophysical Research Communications, 1991We previously observed that Ser378 in the heparin-binding domain of vitronectin becomes phosphorylated by a protein kinase in plasma upon addition of ATP and divalent cations. We now report that purified plasma vitronectin contains approximately 2.5 mol of phosphate per mol of protein and that vitronectin becomes phosphorylated during biosynthesis in ...
J H, Mehringer +2 more
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