Results 181 to 190 of about 34,004 (246)

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

DNA-PKcs and PARP1 at the interface between DNA damage responses and cGAS-STING signaling: context-dependent roles and therapeutic implications. [PDF]

Cancer Biol Ther
Miao T, Zhao J, Wu J, Hou J, Ma T, Wang G.   +5 more
europepmc   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

The CREM-IL-15 axis: decoding the persistence-exhaustion paradox in NK cell immunotherapy. [PDF]

Cancer Immunol Immunother
El-Sehrawy AAMA, Al-Khreisat MJ, Patel JR, Kibriyeva M, Gulnoza L, Qosimov K, Abdul LM, Tailor NK.   +7 more
europepmc   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Structural insights into RNA phosphorylation by the RNase PNK module of the human rixosome complex. [PDF]

Nucleic Acids Res
Gordon J, Seely SM, Wang H, Krahn JM, Peele WA, Borgnia MJ, Warren AJ, Stanley RE.   +7 more
europepmc   +1 more source

Large cyclic AMP-dependent increases in tyrosine-phosphorylated proteins are not absolutely necessary for the induction of full-type hyperactivation and penetration into eggs in ejaculated boar spermatozoa in vitro. [PDF]

J Reprod Dev
Ueshiba A, Nakao R, Morikawa-Tomita R, Kyogoku H, Harayama H.   +4 more
europepmc   +1 more source

Intracellular Ca²⁺ Modulates PKA Compartmentalization and Dynamics in Human iPSC-Derived Cardiomyocytes. [PDF]

Int J Mol Sci
Rotschield A, Mazgaoker S, Segal S, Weiser-Bitoun I, Brosh I, Binah O, Yaniv Y.   +6 more
europepmc   +1 more source

Cross-Talk Between Signaling and Transcriptional Networks Regulating Thermogenesis-Insights into Canonical and Non-Canonical Regulatory Pathways. [PDF]

Int J Mol Sci
Simka-Lampa K.
europepmc   +1 more source